| 8. Ronde | 15.10.2021 | Fulham FC U23 | - | Reading FC U23 | 3:0 | ||||
| 9. Ronde | 25.10.2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | ||||
| 10. Ronde | 01.11.2021 | Reading FC U23 | - | Sunderland AFC U23 | 0:3 | ||||
| 11. Ronde | 08.11.2021 | Reading FC U23 | - | Aston Villa U23 | 2:2 | ||||
| 13. Ronde | 29.11.2021 | Reading FC U23 | - | Middlesbrough FC U23 | 2:1 |  |
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| 14. Ronde | 03.12.2021 | Norwich City U23 | - | Reading FC U23 | 5:2 |  |
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| 18. Ronde | 24.01.2022 | Aston Villa U23 | - | Reading FC U23 | 4:1 | ||||
| 19. Ronde | 07.02.2022 | Reading FC U23 | - | Stoke City U23 | 1:1 | ||||
| 20. Ronde | 21.02.2022 | Nottingham Forest U23 | - | Reading FC U23 | 7:0 | ||||
| 22. Ronde | 14.03.2022 | Reading FC U23 | - | Burnley FC U23 | 2:1 |
België