| 2. Ronde | 14.08.2021 | Accrington Stanley | - | Cambridge United | 2:1 | ||||
| 3. Ronde | 17.08.2021 | Plymouth Argyle | - | Cambridge United | 1:1 | ||||
| 7. Ronde | 11.09.2021 | Cambridge United | - | Lincoln City | 1:5 | ||||
| 10. Ronde | 28.09.2021 | Cambridge United | - | Gillingham FC | 0:2 | ||||
| 14. Ronde | 19.10.2021 | Cambridge United | - | Sheffield Wednesday | 1:1 | ||||
| 15. Ronde | 23.10.2021 | Shrewsbury Town | - | Cambridge United | 4:1 | ||||
| 6. Ronde | 26.10.2021 | Doncaster Rovers | - | Cambridge United | 1:1 | ||||
| 16. Ronde | 30.10.2021 | Cambridge United | - | AFC Wimbledon | 1:0 |  |
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| 12. Ronde | 02.11.2021 | Morecambe FC | - | Cambridge United | 0:2 | ||||
| 17. Ronde | 13.11.2021 | Milton Keynes Dons | - | Cambridge United | 4:1 | ||||
| 18. Ronde | 20.11.2021 | Rotherham United | - | Cambridge United | 3:1 | ||||
| 19. Ronde | 23.11.2021 | Cambridge United | - | Wigan Athletic | 2:2 |  |
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| 21. Ronde | 07.12.2021 | Cheltenham Town | - | Cambridge United | 0:5 | ||||
| 22. Ronde | 11.12.2021 | Charlton Athletic | - | Cambridge United | 2:0 | ||||
| 23. Ronde | 18.12.2021 | Cambridge United | - | Rotherham United | 0:1 |
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