| 3. Ronde | 28.08.2021 | Manchester United U23 | - | Manchester City U23 | 2:4 | ||||
| 4. Ronde | 11.09.2021 | Arsenal FC U23 | - | Manchester United U23 | 3:1 | ||||
| 5. Ronde | 18.09.2021 | Manchester United U23 | - | Brighton & Hove Albion U23 | 2:1 | ||||
| 6. Ronde | 24.09.2021 | Everton FC U23 | - | Manchester United U23 | 0:1 | ||||
| 9. Ronde | 23.10.2021 | West Ham United U23 | - | Manchester United U23 | 6:0 | ||||
| 10. Ronde | 30.10.2021 | Tottenham Hotspur U23 | - | Manchester United U23 | 1:0 | ||||
| 16. Ronde | 10.01.2022 | Manchester United U23 | - | Tottenham Hotspur U23 | 1:1 | ||||
| 17. Ronde | 15.01.2022 | Manchester City U23 | - | Manchester United U23 | 3:1 |  |
Engeland