| 1. Ronde | 07.08.2021 | Tranmere Rovers | - | Walsall FC | 1:0 |  |
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| 2. Ronde | 14.08.2021 | Port Vale FC | - | Tranmere Rovers | 0:0 | ||||
| 3. Ronde | 17.08.2021 | Swindon Town | - | Tranmere Rovers | 0:0 | |
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| 4. Ronde | 21.08.2021 | Tranmere Rovers | - | Newport County | 0:1 | ||||
| 5. Ronde | 28.08.2021 | Scunthorpe United | - | Tranmere Rovers | 1:0 | ||||
| 6. Ronde | 04.09.2021 | Tranmere Rovers | - | Hartlepool United | 1:0 | ||||
| 7. Ronde | 11.09.2021 | Rochdale AFC | - | Tranmere Rovers | 1:0 | ||||
| 36. Ronde | 11.03.2022 | Tranmere Rovers | - | Mansfield Town | 3:2 | ||||
| 37. Ronde | 15.03.2022 | Tranmere Rovers | - | Harrogate Town | 2:0 | |
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| 38. Ronde | 19.03.2022 | Sutton United | - | Tranmere Rovers | 1:1 | ||||
| 39. Ronde | 26.03.2022 | Colchester United | - | Tranmere Rovers | 1:0 | ||||
| 40. Ronde | 02.04.2022 | Tranmere Rovers | - | Carlisle United | 2:2 | |
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| 41. Ronde | 09.04.2022 | Tranmere Rovers | - | Bristol Rovers | 1:1 | ||||
| 42. Ronde | 15.04.2022 | Bradford City | - | Tranmere Rovers | 1:1 | ||||
| 43. Ronde | 18.04.2022 | Tranmere Rovers | - | Exeter City | 2:0 | ||||
| 45. Ronde | 30.04.2022 | Tranmere Rovers | - | Oldham Athletic | 2:0 | ||||
| 46. Ronde | 07.05.2022 | Leyton Orient | - | Tranmere Rovers | 0:1 |
Ierland