| 24. Ronde | 09.02.2022 | Manchester City | - | Brentford FC | 2:0 | ||||
| 25. Ronde | 12.02.2022 | Brentford FC | - | Crystal Palace | 0:0 | ||||
| 26. Ronde | 19.02.2022 | Arsenal FC | - | Brentford FC | 2:1 | ||||
| 27. Ronde | 26.02.2022 | Brentford FC | - | Newcastle United | 0:2 |  |
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| 34. Ronde | 23.04.2022 | Brentford FC | - | Tottenham Hotspur | 0:0 | ||||
| 35. Ronde | 02.05.2022 | Manchester United | - | Brentford FC | 3:0 | ||||
| 36. Ronde | 07.05.2022 | Brentford FC | - | Southampton FC | 3:0 | ||||
| 37. Ronde | 15.05.2022 | Everton FC | - | Brentford FC | 2:3 | ||||
| 38. Ronde | 22.05.2022 | Brentford FC | - | Leeds United | 1:2 |
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