| 3. Ronde | 27.08.2021 | UD Las Palmas | - | SD Huesca | 2:1 | ||||
| 4. Ronde | 06.09.2021 | SD Huesca | - | Real Oviedo | 1:2 | ||||
| 5. Ronde | 13.09.2021 | CD Lugo | - | SD Huesca | 3:2 | ||||
| 6. Ronde | 19.09.2021 | SD Huesca | - | CF Fuenlabrada | 0:0 | ||||
| 7. Ronde | 24.09.2021 | Real Sociedad B | - | SD Huesca | 0:2 | ||||
| 8. Ronde | 02.10.2021 | SD Huesca | - | CD Tenerife | 1:2 | ||||
| 11. Ronde | 19.10.2021 | SD Huesca | - | Málaga CF | 0:0 | ||||
| 12. Ronde | 24.10.2021 | Burgos CF | - | SD Huesca | 3:1 | ||||
| 13. Ronde | 30.10.2021 | SD Huesca | - | SD Amorebieta | 1:1 | ||||
| 15. Ronde | 05.11.2021 | SD Huesca | - | CD Leganés | 0:2 | ||||
| 16. Ronde | 13.11.2021 | CD Mirandés | - | SD Huesca | 0:1 | ||||
| 18. Ronde | 27.11.2021 | UD Almería | - | SD Huesca | 0:0 | ||||
| 22. Ronde | 02.01.2022 | SD Huesca | - | Girona FC | 0:1 | ||||
| 23. Ronde | 08.01.2022 | FC Cartagena | - | SD Huesca | 0:3 |  |
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| 24. Ronde | 23.01.2022 | SD Huesca | - | SD Ponferradina | 1:2 | ||||
| 29. Ronde | 26.02.2022 | UD Ibiza | - | SD Huesca | 2:1 | ||||
| 33. Ronde | 27.03.2022 | Málaga CF | - | SD Huesca | 0:2 | ||||
| 41. Ronde | 21.05.2022 | SD Huesca | - | Real Sociedad B | 3:2 |  |
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| 42. Ronde | 29.05.2022 | Real Valladolid | - | SD Huesca | 3:0 |
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