| 2. Ronde | 23.08.2021 | Nottingham Forest U23 | - | Southampton FC U23 | 0:0 | ||||
| 4. Ronde | 10.09.2021 | Fulham FC U23 | - | Southampton FC U23 | 3:0 | ||||
| 5. Ronde | 19.09.2021 | Southampton FC U23 | - | Burnley FC U23 | 0:2 | ||||
| 6. Ronde | 27.09.2021 | Birmingham City U23 | - | Southampton FC U23 | 3:2 | ||||
| 7. Ronde | 01.10.2021 | Southampton FC U23 | - | Stoke City U23 | 1:1 | ||||
| 9. Ronde | 25.10.2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | ||||
| 11. Ronde | 05.11.2021 | Southampton FC U23 | - | Newcastle United U23 | 5:0 | ||||
| 12. Ronde | 21.11.2021 | Sunderland AFC U23 | - | Southampton FC U23 | 3:2 | ||||
| 15. Ronde | 17.12.2021 | Norwich City U23 | - | Southampton FC U23 | 4:3 | ||||
| 17. Ronde | 17.01.2022 | Southampton FC U23 | - | Fulham FC U23 | 2:1 | ||||
| 18. Ronde | 23.01.2022 | Southampton FC U23 | - | Middlesbrough FC U23 | 1:0 | ||||
| 20. Ronde | 21.02.2022 | Southampton FC U23 | - | Birmingham City U23 | 2:3 | ||||
| 16. Ronde | 25.03.2022 | Southampton FC U23 | - | Wolverhampton Wanderers U23 | 2:4 | ||||
| 24. Ronde | 02.04.2022 | Burnley FC U23 | - | Southampton FC U23 | 2:1 |
Engeland