| 6. Ronde | 27.09.2021 | Burnley FC U23 | - | Reading FC U23 | 3:1 | ||||
| 8. Ronde | 15.10.2021 | Fulham FC U23 | - | Reading FC U23 | 3:0 | ||||
| 9. Ronde | 25.10.2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | ||||
| 10. Ronde | 01.11.2021 | Reading FC U23 | - | Sunderland AFC U23 | 0:3 | ||||
| 11. Ronde | 08.11.2021 | Reading FC U23 | - | Aston Villa U23 | 2:2 | ||||
| 12. Ronde | 22.11.2021 | West Bromwich Albion U23 | - | Reading FC U23 | 1:1 |  |
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| 14. Ronde | 03.12.2021 | Norwich City U23 | - | Reading FC U23 | 5:2 |  |
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| 18. Ronde | 24.01.2022 | Aston Villa U23 | - | Reading FC U23 | 4:1 | ||||
| 21. Ronde | 28.02.2022 | Wolverhampton Wanderers U23 | - | Reading FC U23 | 4:3 | ||||
| 15. Ronde | 06.03.2022 | Birmingham City U23 | - | Reading FC U23 | 0:0 | |
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| 23. Ronde | 20.03.2022 | Southampton FC U23 | - | Reading FC U23 | 2:1 | ||||
| 24. Ronde | 01.04.2022 | Reading FC U23 | - | West Bromwich Albion U23 | 1:1 | ||||
| 25. Ronde | 25.04.2022 | Reading FC U23 | - | Fulham FC U23 | 3:1 |
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