| 1. Ronde | 11.09.2021 | SC Paderborn 07 [A-jun] | - | Wuppertaler SV [A-jun] | 1:1 | ||||
| 2. Ronde | 19.09.2021 | Wuppertaler SV [A-jun] | - | Fortuna Köln [A-jun] | 2:1 | ||||
| 3. Ronde | 26.09.2021 | MSV Duisburg [A-jun] | - | Wuppertaler SV [A-jun] | 0:1 | ||||
| 4. Ronde | 02.10.2021 | Wuppertaler SV [A-jun] | - | Arminia Bielefeld [A-jun] | 0:1 | ||||
| 5. Ronde | 17.10.2021 | FC Schalke 04 [A-jun] | - | Wuppertaler SV [A-jun] | 8:0 |  |
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| 6. Ronde | 24.10.2021 | Wuppertaler SV [A-jun] | - | 1. FC Köln [A-jun] | 0:4 | ||||
| 7. Ronde | 30.10.2021 | Fortuna Düsseldorf [A-jun] | - | Wuppertaler SV [A-jun] | 0:2 | ||||
| 8. Ronde | 28.11.2021 | Wuppertaler SV [A-jun] | - | Alemannia Aachen [A-jun] | 2:1 | ||||
| 9. Ronde | 05.12.2021 | Bayer Leverkusen [A-jun] | - | Wuppertaler SV [A-jun] | 7:0 | ||||
| 11. Ronde | 13.02.2022 | Wuppertaler SV [A-jun] | - | Borussia Dortmund [A-jun] | 0:4 | ||||
| 12. Ronde | 20.02.2022 | Viktoria Köln [A-jun] | - | Wuppertaler SV [A-jun] | 4:0 | ||||
| 13. Ronde | 05.03.2022 | Wuppertaler SV [A-jun] | - | Bor. Mönchengladbach [A-jun] | 1:1 | ||||
| 14. Ronde | 03.04.2022 | VfL Bochum [A-jun] | - | Wuppertaler SV [A-jun] | 3:0 |
Duitsland