| 2. Ronde | 23.08.2021 | Nottingham Forest U23 | - | Southampton FC U23 | 0:0 | ||||
| 3. Ronde | 29.08.2021 | Middlesbrough FC U23 | - | Southampton FC U23 | 2:1 | ||||
| 4. Ronde | 10.09.2021 | Fulham FC U23 | - | Southampton FC U23 | 3:0 | ||||
| 9. Ronde | 25.10.2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 |  |
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| 15. Ronde | 17.12.2021 | Norwich City U23 | - | Southampton FC U23 | 4:3 | ||||
| 19. Ronde | 07.02.2022 | West Bromwich Albion U23 | - | Southampton FC U23 | 0:1 | |
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| 26. Ronde | 01.05.2022 | Southampton FC U23 | - | Sunderland AFC U23 | 1:0 |
Noord-Ierland