| 1. Ronde | 11.09.2021 | Alemannia Aachen [B-jun] | - | Rot-Weiss Essen [B-jun] | 1:0 | ||||
| 2. Ronde | 19.09.2021 | Rot-Weiss Essen [B-jun] | - | Fortuna Köln [B-jun] | 2:0 | ||||
| 3. Ronde | 25.09.2021 | FC Hennef 05 [B-jun] | - | Rot-Weiss Essen [B-jun] | 0:1 | ||||
| 4. Ronde | 03.10.2021 | Rot-Weiss Essen [B-jun] | - | FC Schalke 04 [B-jun] | 0:4 | ||||
| 5. Ronde | 10.10.2021 | SC Paderborn 07 [B-jun] | - | Rot-Weiss Essen [B-jun] | 4:2 |  |
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| 7. Ronde | 06.11.2021 | Rot-Weiss Essen [B-jun] | - | 1. FC Köln [B-jun] | 2:0 |  |
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| 10. Ronde | 11.12.2021 | Bor. Mönchengladbach [B-jun] | - | Rot-Weiss Essen [B-jun] | 4:0 | ||||
| 9. Ronde | 06.02.2022 | Rot-Weiss Essen [B-jun] | - | SG Unterrath 12/24 [B-jun] | 3:1 | ||||
| 8. Ronde | 12.02.2022 | Wuppertaler SV [B-jun] | - | Rot-Weiss Essen [B-jun] | 0:1 | ||||
| 11. Ronde | 20.02.2022 | Rot-Weiss Essen [B-jun] | - | Borussia Dortmund [B-jun] | 1:5 | ||||
| 12. Ronde | 26.02.2022 | Fortuna Düsseldorf [B-jun] | - | Rot-Weiss Essen [B-jun] | 4:0 | ||||
| 13. Ronde | 05.03.2022 | Rot-Weiss Essen [B-jun] | - | Arminia Bielefeld [B-jun] | 1:2 | ||||
| 15. Ronde | 02.04.2022 | Rot-Weiss Essen [B-jun] | - | SV Lippstadt 08 [B-jun] | 0:3 | |
Duitsland