| 6. Ronde | 24.10.2021 | Rot-Weiss Essen [A-jun] | - | Rot-Weiß Oberhausen [A-jun] | 1:0 |  |
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| 7. Ronde | 31.10.2021 | SC Paderborn 07 [A-jun] | - | Rot-Weiss Essen [A-jun] | 3:4 | ||||
| 11. Ronde | 13.02.2022 | FC Schalke 04 [A-jun] | - | Rot-Weiss Essen [A-jun] | 1:2 | ||||
| 13. Ronde | 06.03.2022 | Fortuna Düsseldorf [A-jun] | - | Rot-Weiss Essen [A-jun] | 1:1 | ||||
| 15. Ronde | 09.04.2022 | Bayer Leverkusen [A-jun] | - | Rot-Weiss Essen [A-jun] | 1:0 | |
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| 16. Ronde | 23.04.2022 | Rot-Weiss Essen [A-jun] | - | Wuppertaler SV [A-jun] | 2:1 | |
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| 17. Ronde | 30.04.2022 | Borussia Dortmund [A-jun] | - | Rot-Weiss Essen [A-jun] | 1:0 |
Duitsland