| 1. Ronde | 24.07.2021 | FC Lausanne-Sport | - | FC St. Gallen | 1:2 | ||||
| 2. Ronde | 01.08.2021 | FC St. Gallen | - | FC Luzern | 2:2 | ||||
| 3. Ronde | 08.08.2021 | FC Lugano | - | FC St. Gallen | 2:1 | ||||
| 4. Ronde | 21.08.2021 | FC St. Gallen | - | FC Sion | 1:1 | ||||
| 5. Ronde | 28.08.2021 | FC St. Gallen | - | FC Zürich | 3:3 |  |
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| 6. Ronde | 12.09.2021 | Servette FC | - | FC St. Gallen | 5:1 | ||||
| 7. Ronde | 22.09.2021 | FC St. Gallen | - | FC Basel 1893 | 0:2 | ||||
| 10. Ronde | 17.10.2021 | FC St. Gallen | - | Servette FC | 2:1 | ||||
| 11. Ronde | 24.10.2021 | FC Luzern | - | FC St. Gallen | 2:0 | ||||
| 12. Ronde | 30.10.2021 | FC St. Gallen | - | BSC Young Boys | 3:1 | |
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| 16. Ronde | 05.12.2021 | FC St. Gallen | - | Grasshopper Club Zürich | 0:4 | ||||
| 17. Ronde | 11.12.2021 | FC St. Gallen | - | FC Lugano | 1:1 | ||||
| 18. Ronde | 18.12.2021 | FC Zürich | - | FC St. Gallen | 3:1 |
Mali