| 1. Ronde | 07.08.2021 | Tranmere Rovers | - | Walsall FC | 1:0 | ||||
| 2. Ronde | 14.08.2021 | Port Vale FC | - | Tranmere Rovers | 0:0 | ||||
| 3. Ronde | 17.08.2021 | Swindon Town | - | Tranmere Rovers | 0:0 | ||||
| 4. Ronde | 21.08.2021 | Tranmere Rovers | - | Newport County | 0:1 | ||||
| 5. Ronde | 28.08.2021 | Scunthorpe United | - | Tranmere Rovers | 1:0 | ||||
| 15. Ronde | 30.10.2021 | Mansfield Town | - | Tranmere Rovers | 2:0 | ||||
| 16. Ronde | 13.11.2021 | Tranmere Rovers | - | Sutton United | 0:1 | ||||
| 17. Ronde | 20.11.2021 | Bristol Rovers | - | Tranmere Rovers | 2:2 |  |
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| 18. Ronde | 23.11.2021 | Tranmere Rovers | - | Bradford City | 2:1 | |
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| 26. Ronde | 08.01.2022 | Tranmere Rovers | - | Scunthorpe United | 4:0 | ||||
| 25. Ronde | 11.01.2022 | Salford City | - | Tranmere Rovers | 1:1 | |
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| 19. Ronde | 01.02.2022 | Tranmere Rovers | - | Stevenage FC | 1:0 | ||||
| 30. Ronde | 05.02.2022 | Barrow AFC | - | Tranmere Rovers | 1:1 | ||||
| 31. Ronde | 08.02.2022 | Tranmere Rovers | - | Swindon Town | 3:0 | |
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| 35. Ronde | 05.03.2022 | Northampton Town | - | Tranmere Rovers | 3:2 | ||||
| 36. Ronde | 11.03.2022 | Tranmere Rovers | - | Mansfield Town | 3:2 |
Engeland