| 1. Ronde | 11.09.2021 | SC Paderborn 07 [A-jun] | - | Wuppertaler SV [A-jun] | 1:1 | ||||
| 2. Ronde | 19.09.2021 | Borussia Dortmund [A-jun] | - | SC Paderborn 07 [A-jun] | 3:1 | ||||
| 3. Ronde | 26.09.2021 | SC Paderborn 07 [A-jun] | - | Viktoria Köln [A-jun] | 1:2 | ||||
| 4. Ronde | 02.10.2021 | Bor. Mönchengladbach [A-jun] | - | SC Paderborn 07 [A-jun] | 3:2 |  |
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| 5. Ronde | 16.10.2021 | SC Paderborn 07 [A-jun] | - | VfL Bochum [A-jun] | 1:2 | ||||
| 6. Ronde | 23.10.2021 | Preußen Münster [A-jun] | - | SC Paderborn 07 [A-jun] | 2:4 | ||||
| 7. Ronde | 31.10.2021 | SC Paderborn 07 [A-jun] | - | Rot-Weiss Essen [A-jun] | 3:4 | ||||
| 8. Ronde | 27.11.2021 | Rot-Weiß Oberhausen [A-jun] | - | SC Paderborn 07 [A-jun] | 1:0 |
Duitsland