| 1. Ronde | 07.08.2021 | Northampton Town | - | Port Vale FC | 1:0 | ||||
| 5. Ronde | 28.08.2021 | Forest Green Rovers | - | Port Vale FC | 0:2 | ||||
| 6. Ronde | 04.09.2021 | Port Vale FC | - | Rochdale AFC | 2:3 | ||||
| 7. Ronde | 11.09.2021 | Swindon Town | - | Port Vale FC | 1:2 |  |
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| 8. Ronde | 18.09.2021 | Port Vale FC | - | Harrogate Town | 2:0 | |
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| 9. Ronde | 25.09.2021 | Scunthorpe United | - | Port Vale FC | 0:1 | ||||
| 10. Ronde | 02.10.2021 | Port Vale FC | - | Leyton Orient | 3:2 | ||||
| 11. Ronde | 09.10.2021 | Sutton United | - | Port Vale FC | 4:3 |  |
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| 12. Ronde | 16.10.2021 | Port Vale FC | - | Barrow AFC | 3:1 | ||||
| 13. Ronde | 19.10.2021 | Mansfield Town | - | Port Vale FC | 1:1 | |
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| 14. Ronde | 23.10.2021 | Port Vale FC | - | Colchester United | 3:0 | ||||
| 15. Ronde | 30.10.2021 | Crawley Town | - | Port Vale FC | 1:4 | |
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| 16. Ronde | 13.11.2021 | Port Vale FC | - | Bradford City | 1:1 | ||||
| 17. Ronde | 20.11.2021 | Oldham Athletic | - | Port Vale FC | 3:2 | ||||
| 18. Ronde | 23.11.2021 | Port Vale FC | - | Walsall FC | 0:1 |  |
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| 20. Ronde | 07.12.2021 | Bristol Rovers | - | Port Vale FC | 1:2 | ||||
| 21. Ronde | 11.12.2021 | Newport County | - | Port Vale FC | 2:1 | ||||
| 27. Ronde | 15.01.2022 | Port Vale FC | - | Swindon Town | 1:3 |
Engeland