| 2. Ronde | 14.08.2021 | Portsmouth FC | - | Crewe Alexandra | 2:0 | ||||
| 5. Ronde | 28.08.2021 | Charlton Athletic | - | Crewe Alexandra | 2:0 | ||||
| 7. Ronde | 11.09.2021 | Shrewsbury Town | - | Crewe Alexandra | 1:1 | ||||
| 8. Ronde | 18.09.2021 | Crewe Alexandra | - | Burton Albion | 2:0 | ||||
| 6. Ronde | 21.09.2021 | Crewe Alexandra | - | Morecambe FC | 1:3 | ||||
| 9. Ronde | 25.09.2021 | Rotherham United | - | Crewe Alexandra | 1:1 |  |
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| 10. Ronde | 28.09.2021 | Plymouth Argyle | - | Crewe Alexandra | 1:1 | ||||
| 11. Ronde | 02.10.2021 | Crewe Alexandra | - | Cambridge United | 2:2 | ||||
| 13. Ronde | 16.10.2021 | Fleetwood Town | - | Crewe Alexandra | 3:0 | ||||
| 14. Ronde | 19.10.2021 | Crewe Alexandra | - | Sunderland AFC | 0:4 | ||||
| 15. Ronde | 23.10.2021 | Wycombe Wanderers | - | Crewe Alexandra | 2:1 | ||||
| 16. Ronde | 30.10.2021 | Crewe Alexandra | - | Milton Keynes Dons | 1:4 | ||||
| 23. Ronde | 01.02.2022 | Gillingham FC | - | Crewe Alexandra | 1:0 | ||||
| 32. Ronde | 08.02.2022 | Crewe Alexandra | - | Plymouth Argyle | 1:4 |
Engeland