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| 30.04.2022 | 13:00 | VfL Wolfsburg | - | Werder Bremen | 1:1 (1:0) | |
| 13:00 | Hallescher FC | - | Hertha BSC | 1:2 (0:1) | ||
| 13:00 | FC Viktoria 1889 Berlin | - | 1. FC Magdeburg | 2:0 (0:0) | ||
| 13:00 | Dynamo Dresden | - | 1. FC Union Berlin | 1:1 (0:0) | ||
| 13:00 | Eimsbütteler TV | - | Hannover 96 | 0:4 (0:1) | ||
| 13:00 | Chemnitzer FC | - | Hansa Rostock | 0:2 (0:1) | ||
| 13:00 | RB Leipzig | - | Energie Cottbus | 1:1 (0:1) | ||
| 13:00 | Holstein Kiel | - | Hamburger SV | 2:0 (0:0) | ||
| 13:00 | VfL Osnabrück | - | FC St. Pauli | 1:9 (1:3) |
| » Stand | Heenronde | Returnronde | 1e helft | 2e helft |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Hertha BSC | 18 | 14 | 2 | 2 | 46:22 | 24 | 44 |
| 2 |
|
Energie Cottbus | 18 | 12 | 3 | 3 | 32:19 | 13 | 39 |
| 3 |
|
RB Leipzig | 18 | 11 | 4 | 3 | 44:20 | 24 | 37 |
| 4 |
|
Werder Bremen | 18 | 10 | 2 | 6 | 43:37 | 6 | 32 |
| 5 |
|
Holstein Kiel | 18 | 10 | 2 | 6 | 28:25 | 3 | 32 |
| 6 |
|
FC Viktoria 1889 Berlin | 18 | 8 | 6 | 4 | 31:20 | 11 | 30 |
| 7 |
|
VfL Wolfsburg | 18 | 7 | 6 | 5 | 22:21 | 1 | 27 |
| 8 |
|
1. FC Union Berlin | 18 | 7 | 5 | 6 | 26:27 | -1 | 26 |
| 9 |
|
Hannover 96 | 18 | 7 | 4 | 7 | 25:22 | 3 | 25 |
| 10 |
|
Hamburger SV | 18 | 7 | 4 | 7 | 35:33 | 2 | 25 |
| 11 |
|
Hansa Rostock | 18 | 7 | 3 | 8 | 32:24 | 8 | 24 |
| 12 |
|
Dynamo Dresden | 18 | 6 | 4 | 8 | 26:23 | 3 | 22 |
| 13 |
|
1. FC Magdeburg | 18 | 6 | 3 | 9 | 33:31 | 2 | 21 |
| 14 |
|
FC St. Pauli | 18 | 6 | 3 | 9 | 34:36 | -2 | 21 |
| 15 |
|
Hallescher FC | 18 | 6 | 3 | 9 | 19:34 | -15 | 21 |
| 16 |
|
VfL Osnabrück | 18 | 5 | 4 | 9 | 21:41 | -20 | 19 |
| 17 |
|
Chemnitzer FC | 18 | 4 | 4 | 10 | 16:30 | -14 | 16 |
| 18 |
|
Eimsbütteler TV | 18 | 3 | 4 | 11 | 18:37 | -19 | 13 |
| 19 |
|
FC Carl Zeiss Jena | 18 | 1 | 2 | 15 | 12:41 | -29 | 5 |
| Play-offs | |
| Degradatie |
