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| 23.04.2022 | 15:00 | Gençlerbirliği | - | Bandırmaspor | 2:0 (1:0) | |
| 19:30 | Bursaspor | - | Denizlispor | 1:0 (1:0) | ||
| 24.04.2022 | 12:30 | Boluspor | - | Ümraniyespor | 0:2 (0:2) | |
| 12:30 | Keçiörengücü | - | Menemen Belediyespor | 1:0 (1:0) | ||
| 15:00 | Kocaelispor | - | Manisa FK | 2:1 (2:1) | ||
| 19:30 | Balıkesirspor | - | MKE Ankaragücü | 0:2 (0:1) | ||
| 19:30 | İstanbulspor AŞ | - | BB Erzurumspor | 1:2 (0:1) | ||
| 25.04.2022 | 13:30 | Tuzlaspor | - | Adanaspor | 4:1 (2:1) | |
| 19:30 | Samsunspor | - | Altınordu FK | 2:1 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 33 | 20 | 6 | 7 | 53:28 | 25 | 66 |
| 2 |
|
Ümraniyespor | 32 | 19 | 6 | 7 | 54:31 | 23 | 63 |
| 3 |
|
Bandırmaspor | 32 | 17 | 4 | 11 | 47:29 | 18 | 55 |
| 4 |
|
İstanbulspor AŞ | 32 | 16 | 6 | 10 | 54:38 | 16 | 54 |
| 5 |
|
BB Erzurumspor | 32 | 15 | 9 | 8 | 51:36 | 15 | 54 |
| 6 |
|
Eyüpspor | 32 | 13 | 12 | 7 | 48:38 | 10 | 51 |
| 7 |
|
Samsunspor | 32 | 12 | 10 | 10 | 49:42 | 7 | 46 |
| 8 |
|
Manisa FK | 33 | 13 | 7 | 13 | 39:38 | 1 | 46 |
| 9 |
|
Tuzlaspor | 32 | 12 | 9 | 11 | 38:33 | 5 | 45 |
| 10 |
|
Adanaspor | 33 | 12 | 8 | 13 | 37:37 | 0 | 44 |
| 11 |
|
Gençlerbirliği | 32 | 12 | 6 | 14 | 36:46 | -10 | 42 |
| 12 |
|
Keçiörengücü | 32 | 11 | 8 | 13 | 38:42 | -4 | 41 |
| 13 |
|
Altınordu FK | 33 | 13 | 2 | 18 | 40:57 | -17 | 41 |
| 14 |
|
Kocaelispor | 32 | 11 | 7 | 14 | 33:43 | -10 | 40 |
| 15 |
|
Denizlispor | 32 | 11 | 6 | 15 | 38:48 | -10 | 39 |
| 16 |
|
Boluspor | 32 | 10 | 8 | 14 | 34:40 | -6 | 38 |
| 17 |
|
Menemen Belediyespor | 32 | 8 | 13 | 11 | 39:50 | -11 | 37 |
| 18 |
|
Bursaspor | 32 | 9 | 8 | 15 | 34:46 | -12 | 35 |
| 19 |
|
Balıkesirspor | 32 | 3 | 3 | 26 | 23:63 | -40 | 12 |
| Promotie | |
| Play-offs | |
| Degradatie |
