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| 01.05.2022 | 15:00 | Adanaspor | - | Boluspor | 1:2 (1:1) | |
| 15:00 | MKE Ankaragücü | - | Samsunspor | 0:0 (0:0) | ||
| 15:00 | Bandırmaspor | - | Keçiörengücü | 0:2 (0:0) | ||
| 15:00 | Denizlispor | - | Gençlerbirliği | 2:1 (0:1) | ||
| 15:00 | BB Erzurumspor | - | Kocaelispor | 1:0 (0:0) | ||
| 15:00 | Eyüpspor | - | İstanbulspor AŞ | 1:2 (0:0) | ||
| 15:00 | Manisa FK | - | Bursaspor | 1:3 (1:1) | ||
| 15:00 | Menemen Belediyespor | - | Tuzlaspor | 1:1 (1:0) | ||
| 15:00 | Ümraniyespor | - | Balıkesirspor | 4:1 (3:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 34 | 20 | 7 | 7 | 53:28 | 25 | 67 |
| 2 |
|
Ümraniyespor | 33 | 20 | 6 | 7 | 58:32 | 26 | 66 |
| 3 |
|
İstanbulspor AŞ | 33 | 17 | 6 | 10 | 56:39 | 17 | 57 |
| 4 |
|
BB Erzurumspor | 33 | 16 | 9 | 8 | 52:36 | 16 | 57 |
| 5 |
|
Bandırmaspor | 33 | 17 | 4 | 12 | 47:31 | 16 | 55 |
| 6 |
|
Eyüpspor | 33 | 13 | 12 | 8 | 49:40 | 9 | 51 |
| 7 |
|
Samsunspor | 33 | 12 | 11 | 10 | 49:42 | 7 | 47 |
| 8 |
|
Tuzlaspor | 33 | 12 | 10 | 11 | 39:34 | 5 | 46 |
| 9 |
|
Manisa FK | 34 | 13 | 7 | 14 | 40:41 | -1 | 46 |
| 10 |
|
Keçiörengücü | 33 | 12 | 8 | 13 | 40:42 | -2 | 44 |
| 11 |
|
Adanaspor | 34 | 12 | 8 | 14 | 38:39 | -1 | 44 |
| 12 |
|
Denizlispor | 33 | 12 | 6 | 15 | 40:49 | -9 | 42 |
| 13 |
|
Gençlerbirliği | 33 | 12 | 6 | 15 | 37:48 | -11 | 42 |
| 14 |
|
Boluspor | 33 | 11 | 8 | 14 | 36:41 | -5 | 41 |
| 15 |
|
Altınordu FK | 33 | 13 | 2 | 18 | 40:57 | -17 | 41 |
| 16 |
|
Kocaelispor | 33 | 11 | 7 | 15 | 33:44 | -11 | 40 |
| 17 |
|
Bursaspor | 33 | 10 | 8 | 15 | 37:47 | -10 | 38 |
| 18 |
|
Menemen Belediyespor | 33 | 8 | 14 | 11 | 40:51 | -11 | 38 |
| 19 |
|
Balıkesirspor | 33 | 3 | 3 | 27 | 24:67 | -43 | 12 |
| Promotie | |
| Play-offs | |
| Degradatie |
