| 1. Ronde | 16.08.2021 | Blackburn Rovers U23 | - | Everton FC U23 | 2:2 |  |
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| 2. Ronde | 23.08.2021 | Everton FC U23 | - | Liverpool FC U23 | 1:3 |  |
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| 3. Ronde | 27.08.2021 | Crystal Palace U23 | - | Everton FC U23 | 3:1 | |
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| 4. Ronde | 10.09.2021 | Everton FC U23 | - | Derby County U23 | 1:0 | |
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| 5. Ronde | 20.09.2021 | Leicester City U23 | - | Everton FC U23 | 3:1 | ||||
| 6. Ronde | 24.09.2021 | Everton FC U23 | - | Manchester United U23 | 0:1 |  |
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| 8. Ronde | 18.10.2021 | Everton FC U23 | - | Leeds United U23 | 4:2 | |
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| 9. Ronde | 22.10.2021 | Arsenal FC U23 | - | Everton FC U23 | 4:0 | ||||
| 10. Ronde | 30.10.2021 | Chelsea FC U23 | - | Everton FC U23 | 1:1 | ||||
| 11. Ronde | 06.11.2021 | Everton FC U23 | - | Manchester City U23 | 3:2 | |
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| 15. Ronde | 20.12.2021 | Leeds United U23 | - | Everton FC U23 | 0:0 | ||||
| 24. Ronde | 04.04.2022 | Everton FC U23 | - | Blackburn Rovers U23 | 0:2 | ||||
| 21. Ronde | 15.04.2022 | Everton FC U23 | - | Chelsea FC U23 | 2:0 | ||||
| 25. Ronde | 25.04.2022 | Everton FC U23 | - | West Ham United U23 | 3:4 | ||||
| 26. Ronde | 29.04.2022 | Manchester City U23 | - | Everton FC U23 | 7:0 |
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