| 1. Ronde | 14.08.2021 | Everton FC | - | Southampton FC | 3:1 |  |
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| 2. Ronde | 21.08.2021 | Leeds United | - | Everton FC | 2:2 | |
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| 3. Ronde | 28.08.2021 | Brighton & Hove Albion | - | Everton FC | 0:2 | |
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| 21. Ronde | 02.01.2022 | Everton FC | - | Brighton & Hove Albion | 2:3 | ||||
| 22. Ronde | 15.01.2022 | Norwich City | - | Everton FC | 2:1 | ||||
| 23. Ronde | 22.01.2022 | Everton FC | - | Aston Villa | 0:1 |  |
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| 25. Ronde | 12.02.2022 | Everton FC | - | Leeds United | 3:0 | ||||
| 26. Ronde | 19.02.2022 | Southampton FC | - | Everton FC | 2:0 | |
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| 28. Ronde | 07.03.2022 | Tottenham Hotspur | - | Everton FC | 5:0 | ||||
| 20. Ronde | 17.03.2022 | Everton FC | - | Newcastle United | 1:0 | ||||
| 31. Ronde | 03.04.2022 | West Ham United | - | Everton FC | 2:1 | ||||
| 19. Ronde | 06.04.2022 | Burnley FC | - | Everton FC | 3:2 | ||||
| 32. Ronde | 09.04.2022 | Everton FC | - | Manchester United | 1:0 | ||||
| 30. Ronde | 11.05.2022 | Watford FC | - | Everton FC | 0:0 | ||||
| 37. Ronde | 15.05.2022 | Everton FC | - | Brentford FC | 2:3 | |
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| 33. Ronde | 19.05.2022 | Everton FC | - | Crystal Palace | 3:2 | |
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| 38. Ronde | 22.05.2022 | Arsenal FC | - | Everton FC | 5:1 |
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