| 3. Ronde | 27.08.2021 | Crystal Palace U23 | - | Everton FC U23 | 3:1 | ||||
| 4. Ronde | 10.09.2021 | Everton FC U23 | - | Derby County U23 | 1:0 | ||||
| 5. Ronde | 20.09.2021 | Leicester City U23 | - | Everton FC U23 | 3:1 | ||||
| 7. Ronde | 02.10.2021 | West Ham United U23 | - | Everton FC U23 | 3:1 | ||||
| 8. Ronde | 18.10.2021 | Everton FC U23 | - | Leeds United U23 | 4:2 |  |
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| 9. Ronde | 22.10.2021 | Arsenal FC U23 | - | Everton FC U23 | 4:0 | ||||
| 10. Ronde | 30.10.2021 | Chelsea FC U23 | - | Everton FC U23 | 1:1 | ||||
| 14. Ronde | 06.12.2021 | Everton FC U23 | - | Arsenal FC U23 | 2:0 | ||||
| 16. Ronde | 10.01.2022 | Everton FC U23 | - | Crystal Palace U23 | 2:2 | ||||
| 19. Ronde | 04.02.2022 | Everton FC U23 | - | Leicester City U23 | 1:2 | |
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| 20. Ronde | 21.02.2022 | Derby County U23 | - | Everton FC U23 | 0:2 | ||||
| 23. Ronde | 18.03.2022 | Manchester United U23 | - | Everton FC U23 | 3:0 | ||||
| 24. Ronde | 04.04.2022 | Everton FC U23 | - | Blackburn Rovers U23 | 0:2 | |
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| 21. Ronde | 15.04.2022 | Everton FC U23 | - | Chelsea FC U23 | 2:0 | |
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| 25. Ronde | 25.04.2022 | Everton FC U23 | - | West Ham United U23 | 3:4 | ||||
| 26. Ronde | 29.04.2022 | Manchester City U23 | - | Everton FC U23 | 7:0 |
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