| 1. Ronde | 15.08.2021 | UD Las Palmas | - | Real Valladolid | 1:1 | ||||
| 2. Ronde | 20.08.2021 | Real Valladolid | - | Real Zaragoza | 2:0 | ||||
| 3. Ronde | 29.08.2021 | CD Lugo | - | Real Valladolid | 0:2 |  |
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| 4. Ronde | 05.09.2021 | Burgos CF | - | Real Valladolid | 3:0 | ||||
| 7. Ronde | 26.09.2021 | Real Valladolid | - | AD Alcorcón | 2:0 | ||||
| 8. Ronde | 01.10.2021 | SD Ponferradina | - | Real Valladolid | 2:2 | ||||
| 10. Ronde | 17.10.2021 | CD Leganés | - | Real Valladolid | 0:2 | ||||
| 11. Ronde | 20.10.2021 | Real Valladolid | - | UD Ibiza | 1:1 | ||||
| 12. Ronde | 23.10.2021 | Sporting Gijón | - | Real Valladolid | 1:2 | ||||
| 13. Ronde | 31.10.2021 | Real Valladolid | - | SD Eibar | 2:0 | ||||
| 14. Ronde | 03.11.2021 | SD Amorebieta | - | Real Valladolid | 4:1 |  |
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| 15. Ronde | 06.11.2021 | Real Valladolid | - | CD Mirandés | 3:1 | ||||
| 17. Ronde | 20.11.2021 | UD Almería | - | Real Valladolid | 3:1 | ||||
| 19. Ronde | 03.12.2021 | SD Huesca | - | Real Valladolid | 3:2 | ||||
| 20. Ronde | 12.12.2021 | Real Valladolid | - | Real Oviedo | 2:1 | ||||
| 22. Ronde | 02.01.2022 | Real Valladolid | - | CD Leganés | 1:0 |
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