| 3. Ronde | 28.08.2021 | Manchester United U23 | - | Manchester City U23 | 2:4 | ||||
| 4. Ronde | 11.09.2021 | Arsenal FC U23 | - | Manchester United U23 | 3:1 | ||||
| 12. Ronde | 19.11.2021 | Derby County U23 | - | Manchester United U23 | 1:1 | ||||
| 20. Ronde | 20.02.2022 | Crystal Palace U23 | - | Manchester United U23 | 2:2 |  |
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| 21. Ronde | 25.02.2022 | Manchester United U23 | - | Derby County U23 | 5:2 |  |
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| 22. Ronde | 15.03.2022 | Leeds United U23 | - | Manchester United U23 | 3:0 | |
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| 23. Ronde | 18.03.2022 | Manchester United U23 | - | Everton FC U23 | 3:0 | |
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| 24. Ronde | 04.04.2022 | Leicester City U23 | - | Manchester United U23 | 3:2 | |
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| 25. Ronde | 22.04.2022 | Manchester United U23 | - | Arsenal FC U23 | 1:1 | ||||
| 26. Ronde | 01.05.2022 | Liverpool FC U23 | - | Manchester United U23 | 3:1 | |
Frankrijk