| 1. Ronde | 16.08.2021 | Crystal Palace U23 | - | Leeds United U23 | 1:3 |  |
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| 2. Ronde | 20.08.2021 | Arsenal FC U23 | - | Crystal Palace U23 | 4:2 | ||||
| 3. Ronde | 27.08.2021 | Crystal Palace U23 | - | Everton FC U23 | 3:1 | |
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| 4. Ronde | 13.09.2021 | Leicester City U23 | - | Crystal Palace U23 | 1:6 | ||||
| 5. Ronde | 18.09.2021 | Manchester City U23 | - | Crystal Palace U23 | 4:2 | |
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| 6. Ronde | 24.09.2021 | West Ham United U23 | - | Crystal Palace U23 | 1:0 | ||||
| 7. Ronde | 01.10.2021 | Crystal Palace U23 | - | Tottenham Hotspur U23 | 4:3 | ||||
| 8. Ronde | 16.10.2021 | Brighton & Hove Albion U23 | - | Crystal Palace U23 | 2:1 | |
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| 9. Ronde | 22.10.2021 | Derby County U23 | - | Crystal Palace U23 | 2:3 | ||||
| 10. Ronde | 01.11.2021 | Crystal Palace U23 | - | Blackburn Rovers U23 | 1:2 | ||||
| 11. Ronde | 06.11.2021 | Chelsea FC U23 | - | Crystal Palace U23 | 1:2 | |
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| 12. Ronde | 20.11.2021 | Liverpool FC U23 | - | Crystal Palace U23 | 0:3 | ||||
| 13. Ronde | 27.11.2021 | Manchester United U23 | - | Crystal Palace U23 | 1:2 | ||||
| 14. Ronde | 06.12.2021 | Crystal Palace U23 | - | West Ham United U23 | 2:4 |
Ierland