| 9. Ronde | 21.11.2020 | Liverpool FC U23 | - | Southampton FC U23 | 0:0 | ||||
| 7. Ronde | 04.12.2020 | Manchester United U23 | - | Southampton FC U23 | 3:1 | ||||
| 16. Ronde | 29.01.2021 | West Ham United U23 | - | Southampton FC U23 | 3:1 | ||||
| 17. Ronde | 07.02.2021 | Southampton FC U23 | - | Tottenham Hotspur U23 | 1:1 | ||||
| 19. Ronde | 21.02.2021 | Southampton FC U23 | - | Derby County U23 | 1:0 |  |
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| 20. Ronde | 27.02.2021 | Southampton FC U23 | - | Manchester United U23 | 1:2 | ||||
| 14. Ronde | 05.03.2021 | Southampton FC U23 | - | Arsenal FC U23 | 2:2 | |
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| 18. Ronde | 08.03.2021 | Blackburn Rovers U23 | - | Southampton FC U23 | 5:1 | ||||
| 23. Ronde | 09.04.2021 | Brighton & Hove Albion U23 | - | Southampton FC U23 | 3:0 | ||||
| 15. Ronde | 12.04.2021 | Chelsea FC U23 | - | Southampton FC U23 | 3:1 | ||||
| 24. Ronde | 19.04.2021 | Leicester City U23 | - | Southampton FC U23 | 7:1 | ||||
| 26. Ronde | 02.05.2021 | Southampton FC U23 | - | Everton FC U23 | 0:5 | ||||
| 13. Ronde | 07.05.2021 | Everton FC U23 | - | Southampton FC U23 | 4:0 |
Engeland