| 5. Ronde | 25.09.2021 | VfB Stuttgart [A-jun] | - | SSV Ulm 1846 [A-jun] | 3:1 |  |
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| 6. Ronde | 02.10.2021 | Bayern München [A-jun] | - | VfB Stuttgart [A-jun] | 1:4 | ||||
| 8. Ronde | 24.10.2021 | 1. FC Saarbrücken [A-jun] | - | VfB Stuttgart [A-jun] | 0:1 | |
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| 10. Ronde | 20.11.2021 | VfB Stuttgart [A-jun] | - | Eintracht Frankfurt [A-jun] | 3:0 | ||||
| 11. Ronde | 27.11.2021 | 1899 Hoffenheim [A-jun] | - | VfB Stuttgart [A-jun] | 2:2 | |
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| 12. Ronde | 04.12.2021 | VfB Stuttgart [A-jun] | - | Hessen Kassel [A-jun] | 7:0 | ||||
| 13. Ronde | 05.02.2022 | 1. FC Nürnberg [A-jun] | - | VfB Stuttgart [A-jun] | 0:2 | ||||
| 14. Ronde | 13.02.2022 | VfB Stuttgart [A-jun] | - | SpVgg Greuther Fürth [A-jun] | 5:1 | |
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| 15. Ronde | 20.02.2022 | 1. FSV Mainz 05 [A-jun] | - | VfB Stuttgart [A-jun] | 0:3 | ||||
| 16. Ronde | 25.02.2022 | VfB Stuttgart [A-jun] | - | Karlsruher SC [A-jun] | 0:1 | ||||
| 17. Ronde | 04.03.2022 | FC-Astoria Walldorf [A-jun] | - | VfB Stuttgart [A-jun] | 3:0 | ||||
| 18. Ronde | 02.04.2022 | VfB Stuttgart [A-jun] | - | FC Ingolstadt 04 [A-jun] | 6:1 | |
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| 19. Ronde | 10.04.2022 | SpVgg Unterhaching [A-jun] | - | VfB Stuttgart [A-jun] | 1:0 |
Portugal