| 1. Ronde | 08.08.2022 | Nottingham Forest U21 | - | Southampton FC U21 | 1:3 | ||||
| 3. Ronde | 19.08.2022 | Stoke City U21 | - | Southampton FC U21 | 0:3 | ||||
| 4. Ronde | 26.08.2022 | Southampton FC U21 | - | Norwich City U21 | 1:1 | ||||
| 8. Ronde | 08.10.2022 | Southampton FC U21 | - | Aston Villa U21 | 2:0 | ||||
| 9. Ronde | 23.10.2022 | Newcastle United U21 | - | Southampton FC U21 | 3:2 | ||||
| 11. Ronde | 07.11.2022 | Sunderland AFC U21 | - | Southampton FC U21 | 1:3 | ||||
| 12. Ronde | 06.01.2023 | Southampton FC U21 | - | Derby County U21 | 3:0 | ||||
| 14. Ronde | 27.01.2023 | Middlesbrough FC U21 | - | Southampton FC U21 | 2:2 | ||||
| 15. Ronde | 10.02.2023 | Southampton FC U21 | - | Sunderland AFC U21 | 2:2 |  |
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| 16. Ronde | 20.02.2023 | West Bromwich Albion U21 | - | Southampton FC U21 | 1:2 | ||||
| 18. Ronde | 03.03.2023 | Southampton FC U21 | - | Nottingham Forest U21 | 0:2 | ||||
| 19. Ronde | 17.03.2023 | Aston Villa U21 | - | Southampton FC U21 | 1:2 | ||||
| 5. Ronde | 31.03.2023 | Derby County U21 | - | Southampton FC U21 | 1:3 | ||||
| 21. Ronde | 14.04.2023 | Southampton FC U21 | - | Stoke City U21 | 2:0 | ||||
| 22. Ronde | 23.04.2023 | Norwich City U21 | - | Southampton FC U21 | 2:5 |
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