| 2. Ronde | 22.08.2021 | SV Darmstadt 98 [B-jun] | - | Karlsruher SC [B-jun] | 2:1 | ||||
| 6. Ronde | 25.09.2021 | 1899 Hoffenheim [B-jun] | - | Karlsruher SC [B-jun] | 3:0 |  |
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| 8. Ronde | 10.10.2021 | Karlsruher SC [B-jun] | - | SV Wehen Wiesbaden [B-jun] | 0:1 | |
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| 12. Ronde | 28.11.2021 | Karlsruher SC [B-jun] | - | SpVgg Unterhaching [B-jun] | 0:1 | |
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| 13. Ronde | 05.12.2021 | FSV Frankfurt [B-jun] | - | Karlsruher SC [B-jun] | 3:2 | ||||
| 14. Ronde | 11.12.2021 | Karlsruher SC [B-jun] | - | 1. FC Nürnberg [B-jun] | 1:1 | ||||
| 15. Ronde | 20.02.2022 | Bayern München [B-jun] | - | Karlsruher SC [B-jun] | 4:4 | ||||
| 16. Ronde | 27.02.2022 | Karlsruher SC [B-jun] | - | Stuttgarter Kickers [B-jun] | 3:0 | ||||
| 17. Ronde | 06.03.2022 | FC Augsburg [B-jun] | - | Karlsruher SC [B-jun] | 0:2 | ||||
| 18. Ronde | 12.03.2022 | Karlsruher SC [B-jun] | - | SpVgg Greuther Fürth [B-jun] | 1:0 | ||||
| 19. Ronde | 02.04.2022 | FC Ingolstadt 04 [B-jun] | - | Karlsruher SC [B-jun] | 0:2 | ||||
| 20. Ronde | 16.04.2022 | Karlsruher SC [B-jun] | - | SSV Reutlingen [B-jun] | 0:0 |
Duitsland
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