| 10. Ronde | 20.11.2021 | 1. FC Saarbrücken [A-jun] | - | 1899 Hoffenheim [A-jun] | 1:3 | ||||
| 6. Ronde | 29.01.2022 | SC Freiburg [A-jun] | - | 1899 Hoffenheim [A-jun] | 3:3 | ||||
| 14. Ronde | 12.02.2022 | 1899 Hoffenheim [A-jun] | - | Hessen Kassel [A-jun] | 5:0 | ||||
| 16. Ronde | 26.02.2022 | 1899 Hoffenheim [A-jun] | - | SpVgg Greuther Fürth [A-jun] | 3:0 |  |
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| 17. Ronde | 05.03.2022 | 1. FSV Mainz 05 [A-jun] | - | 1899 Hoffenheim [A-jun] | 3:2 | ||||
| 12. Ronde | 12.03.2022 | Eintracht Frankfurt [A-jun] | - | 1899 Hoffenheim [A-jun] | 1:0 | ||||
| 21. Ronde | 30.04.2022 | SpVgg Unterhaching [A-jun] | - | 1899 Hoffenheim [A-jun] | 3:2 |
Verenigde Staten