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| 05.12.2021 | 11:00 | 1. FC Nürnberg | - | MSV Duisburg | 1:2 (0:1) | |
| 11:00 | FC Ingolstadt 04 | - | VfL Wolfsburg II | 2:0 (1:0) | ||
| 11:00 | Borussia Bocholt | - | Bayern München II | 0:3 (0:0) | ||
| 14:00 | FSV Gütersloh 2009 | - | SV Meppen | 0:1 (0:0) | ||
| 14:00 | SV 07 Elversberg | - | 1899 Hoffenheim II | 0:4 (0:3) | ||
| 14:00 | SG 99 Andernach | - | Eintracht Frankfurt II | 1:1 (0:1) | ||
| 13.02.2022 | 11:00 | SV Henstedt-Ulzburg | - | RB Leipzig | 2:3 (2:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV Meppen | 11 | 10 | 0 | 1 | 34:6 | 28 | 30 |
| 2 |
|
MSV Duisburg | 11 | 9 | 0 | 2 | 25:11 | 14 | 27 |
| 3 |
|
RB Leipzig | 11 | 7 | 0 | 4 | 30:19 | 11 | 21 |
| 4 |
|
FSV Gütersloh 2009 | 11 | 6 | 1 | 4 | 25:14 | 11 | 19 |
| 5 |
|
1. FC Nürnberg | 11 | 6 | 1 | 4 | 21:13 | 8 | 19 |
| 6 |
|
SG 99 Andernach | 11 | 5 | 2 | 4 | 21:16 | 5 | 17 |
| 7 |
|
Eintracht Frankfurt II | 11 | 5 | 2 | 4 | 21:17 | 4 | 17 |
| 8 |
|
Bayern München II | 11 | 5 | 0 | 6 | 16:20 | -4 | 15 |
| 9 |
|
1899 Hoffenheim II | 11 | 4 | 2 | 5 | 15:16 | -1 | 14 |
| 10 |
|
FC Ingolstadt 04 | 11 | 4 | 0 | 7 | 25:27 | -2 | 12 |
| 11 |
|
Borussia Bocholt | 11 | 3 | 2 | 6 | 14:30 | -16 | 11 |
| 12 |
|
VfL Wolfsburg II | 11 | 2 | 2 | 7 | 7:20 | -13 | 8 |
| 13 |
|
SV 07 Elversberg | 11 | 2 | 2 | 7 | 9:29 | -20 | 8 |
| 14 |
|
SV Henstedt-Ulzburg | 11 | 2 | 0 | 9 | 16:41 | -25 | 6 |
| Promotie | |
| Degradatie |
