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| 27.02.2022 | 11:00 | SV 07 Elversberg | - | SV Meppen | 0:2 (0:2) | |
| 11:00 | FC Ingolstadt 04 | - | Eintracht Frankfurt II | 0:1 (0:0) | ||
| 11:00 | SV Henstedt-Ulzburg | - | 1899 Hoffenheim II | 1:1 (1:1) | ||
| 14:00 | MSV Duisburg | - | FSV Gütersloh 2009 | 1:0 (0:0) | ||
| 14:00 | 1. FC Nürnberg | - | Bayern München II | 4:0 (1:0) | ||
| 14:00 | RB Leipzig | - | VfL Wolfsburg II | 0:0 (0:0) | ||
| 14:00 | Borussia Bocholt | - | SG 99 Andernach | 0:4 (0:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV Meppen | 14 | 12 | 1 | 1 | 40:8 | 32 | 37 |
| 2 |
|
MSV Duisburg | 14 | 11 | 0 | 3 | 30:16 | 14 | 33 |
| 3 |
|
RB Leipzig | 14 | 9 | 1 | 4 | 37:20 | 17 | 28 |
| 4 |
|
1. FC Nürnberg | 14 | 8 | 1 | 5 | 29:15 | 14 | 25 |
| 5 |
|
Eintracht Frankfurt II | 14 | 7 | 2 | 5 | 25:20 | 5 | 23 |
| 6 |
|
SG 99 Andernach | 14 | 6 | 4 | 4 | 29:20 | 9 | 22 |
| 7 |
|
1899 Hoffenheim II | 14 | 6 | 3 | 5 | 20:19 | 1 | 21 |
| 8 |
|
FSV Gütersloh 2009 | 14 | 6 | 2 | 6 | 29:22 | 7 | 20 |
| 9 |
|
Bayern München II | 14 | 6 | 1 | 7 | 20:27 | -7 | 19 |
| 10 |
|
FC Ingolstadt 04 | 14 | 4 | 1 | 9 | 29:33 | -4 | 13 |
| 11 |
|
VfL Wolfsburg II | 14 | 3 | 3 | 8 | 9:24 | -15 | 12 |
| 12 |
|
SV 07 Elversberg | 14 | 3 | 2 | 9 | 10:32 | -22 | 11 |
| 13 |
|
Borussia Bocholt | 14 | 3 | 2 | 9 | 17:40 | -23 | 11 |
| 14 |
|
SV Henstedt-Ulzburg | 14 | 2 | 1 | 11 | 20:48 | -28 | 7 |
| Promotie | |
| Degradatie |
