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| 27.02.2022 | 14:30 | Lucchese | - | Fermana FC | 0:0 (0:0) | |
| 14:30 | Carrarese Calcio | - | AS Gubbio | 1:0 (1:0) | ||
| 14:30 | Olbia Calcio | - | Aquila Montevarchi | 0:0 (0:0) | ||
| 14:30 | ACN Siena 1904 | - | Viterbese | 0:0 (0:0) | ||
| 14:30 | Teramo Calcio | - | US Grosseto FC | 2:1 (1:1) | ||
| 14:30 | Ancona 1905 | - | AC Reggiana 1919 | 1:1 (0:0) | ||
| 14:30 | US Pontedera | - | Cesena FC | 2:0 (1:0) | ||
| 14:30 | Vis Pesaro | - | Virtus Entella | 2:1 (0:1) | ||
| 14:30 | US Pistoiese | - | Imolese Calcio | 3:0 (0:0) | ||
| 28.02.2022 | 21:00 | Modena FC | - | Delfino Pescara | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Modena FC | 29 | 22 | 5 | 2 | 51:17 | 34 | 71 |
| 2 |
|
AC Reggiana 1919 | 29 | 19 | 9 | 1 | 53:17 | 36 | 66 |
| 3 |
|
Cesena FC | 29 | 14 | 10 | 5 | 39:22 | 17 | 52 |
| 4 |
|
Virtus Entella | 29 | 14 | 7 | 8 | 49:33 | 16 | 49 |
| 5 |
|
Delfino Pescara | 29 | 12 | 11 | 6 | 42:32 | 10 | 47 |
| 6 |
|
Ancona 1905 | 29 | 13 | 7 | 9 | 50:38 | 12 | 46 |
| 7 |
|
US Pontedera | 29 | 11 | 6 | 12 | 33:41 | -8 | 39 |
| 8 |
|
Carrarese Calcio | 29 | 8 | 14 | 7 | 29:34 | -5 | 38 |
| 9 |
|
Vis Pesaro | 29 | 9 | 11 | 9 | 28:36 | -8 | 38 |
| 10 |
|
AS Gubbio | 29 | 8 | 13 | 8 | 37:33 | 4 | 37 |
| 11 |
|
ACN Siena 1904 | 29 | 9 | 8 | 12 | 33:33 | 0 | 35 |
| 12 |
|
Lucchese | 29 | 7 | 12 | 10 | 27:30 | -3 | 33 |
| 13 |
|
Teramo Calcio | 29 | 8 | 9 | 12 | 31:48 | -17 | 33 |
| 14 |
|
Olbia Calcio | 29 | 8 | 8 | 13 | 32:39 | -7 | 32 |
| 15 |
|
Aquila Montevarchi | 29 | 8 | 6 | 15 | 30:48 | -18 | 30 |
| 16 |
|
US Pistoiese | 29 | 6 | 9 | 14 | 28:43 | -15 | 27 |
| 17 |
|
Fermana FC | 29 | 5 | 12 | 12 | 21:35 | -14 | 27 |
| 18 |
|
Viterbese | 29 | 5 | 11 | 13 | 30:40 | -10 | 26 |
| 19 |
|
Imolese Calcio | 29 | 6 | 10 | 13 | 31:41 | -10 | 26 |
| 20 |
|
US Grosseto FC | 29 | 3 | 12 | 14 | 23:37 | -14 | 21 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
