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| 06.03.2022 | 14:30 | Modena FC | - | Olbia Calcio | 1:2 (0:2) | |
| 14:30 | Fermana FC | - | Ancona 1905 | 1:0 (1:0) | ||
| 17:30 | Cesena FC | - | Teramo Calcio | 2:0 (1:0) | ||
| 17:30 | AS Gubbio | - | Vis Pesaro | 3:0 (2:0) | ||
| 17:30 | Delfino Pescara | - | ACN Siena 1904 | 2:1 (1:0) | ||
| 17:30 | AC Reggiana 1919 | - | US Pontedera | 2:0 (1:0) | ||
| 17:30 | US Grosseto FC | - | Imolese Calcio | 2:0 (2:0) | ||
| 17:30 | Viterbese | - | Lucchese | 0:1 (0:0) | ||
| 17:30 | Aquila Montevarchi | - | US Pistoiese | 1:1 (1:1) | ||
| 07.03.2022 | 21:00 | Virtus Entella | - | Carrarese Calcio | 3:0 (2:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Modena FC | 30 | 22 | 5 | 3 | 52:19 | 33 | 71 |
| 2 |
|
AC Reggiana 1919 | 30 | 20 | 9 | 1 | 55:17 | 38 | 69 |
| 3 |
|
Cesena FC | 30 | 15 | 10 | 5 | 41:22 | 19 | 55 |
| 4 |
|
Virtus Entella | 30 | 15 | 7 | 8 | 52:33 | 19 | 52 |
| 5 |
|
Delfino Pescara | 30 | 13 | 11 | 6 | 44:33 | 11 | 50 |
| 6 |
|
Ancona 1905 | 30 | 13 | 7 | 10 | 50:39 | 11 | 46 |
| 7 |
|
AS Gubbio | 30 | 9 | 13 | 8 | 40:33 | 7 | 40 |
| 8 |
|
US Pontedera | 30 | 11 | 6 | 13 | 33:43 | -10 | 39 |
| 9 |
|
Carrarese Calcio | 30 | 8 | 14 | 8 | 29:37 | -8 | 38 |
| 10 |
|
Vis Pesaro | 30 | 9 | 11 | 10 | 28:39 | -11 | 38 |
| 11 |
|
Lucchese | 30 | 8 | 12 | 10 | 28:30 | -2 | 36 |
| 12 |
|
ACN Siena 1904 | 30 | 9 | 8 | 13 | 34:35 | -1 | 35 |
| 13 |
|
Olbia Calcio | 30 | 9 | 8 | 13 | 34:40 | -6 | 35 |
| 14 |
|
Teramo Calcio | 30 | 8 | 9 | 13 | 31:50 | -19 | 33 |
| 15 |
|
Aquila Montevarchi | 30 | 8 | 7 | 15 | 31:49 | -18 | 31 |
| 16 |
|
Fermana FC | 30 | 6 | 12 | 12 | 22:35 | -13 | 30 |
| 17 |
|
US Pistoiese | 30 | 6 | 10 | 14 | 29:44 | -15 | 28 |
| 18 |
|
Viterbese | 30 | 5 | 11 | 14 | 30:41 | -11 | 26 |
| 19 |
|
Imolese Calcio | 30 | 6 | 10 | 14 | 31:43 | -12 | 26 |
| 20 |
|
US Grosseto FC | 30 | 4 | 12 | 14 | 25:37 | -12 | 24 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
