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| 15.03.2022 | 14:30 | Viterbese | - | US Pistoiese | 2:2 (1:1) | |
| 18:00 | Carrarese Calcio | - | Olbia Calcio | 1:1 (1:0) | ||
| 18:00 | Modena FC | - | ACN Siena 1904 | 1:1 (1:1) | ||
| 21:00 | AS Gubbio | - | Imolese Calcio | 2:1 (1:1) | ||
| 21:00 | Delfino Pescara | - | Cesena FC | 1:0 (1:0) | ||
| 21:00 | Fermana FC | - | Teramo Calcio | 0:1 (0:0) | ||
| 21:00 | Aquila Montevarchi | - | Lucchese | 2:0 (1:0) | ||
| 21:00 | AC Reggiana 1919 | - | Vis Pesaro | 3:1 (1:1) | ||
| 21:00 | US Grosseto FC | - | US Pontedera | 0:0 (0:0) | ||
| 21:00 | Virtus Entella | - | Ancona 1905 | 2:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Modena FC | 32 | 23 | 6 | 3 | 56:22 | 34 | 75 |
| 2 |
|
AC Reggiana 1919 | 32 | 21 | 9 | 2 | 58:19 | 39 | 72 |
| 3 |
|
Cesena FC | 32 | 16 | 10 | 6 | 42:23 | 19 | 58 |
| 4 |
|
Virtus Entella | 32 | 16 | 8 | 8 | 55:34 | 21 | 56 |
| 5 |
|
Delfino Pescara | 32 | 15 | 11 | 6 | 47:34 | 13 | 56 |
| 6 |
|
Ancona 1905 | 32 | 13 | 8 | 11 | 52:43 | 9 | 47 |
| 7 |
|
AS Gubbio | 32 | 11 | 13 | 8 | 44:35 | 9 | 46 |
| 8 |
|
Vis Pesaro | 32 | 10 | 11 | 11 | 31:43 | -12 | 41 |
| 9 |
|
US Pontedera | 32 | 11 | 7 | 14 | 34:45 | -11 | 40 |
| 10 |
|
Lucchese | 32 | 9 | 12 | 11 | 29:32 | -3 | 39 |
| 11 |
|
Carrarese Calcio | 32 | 8 | 15 | 9 | 32:41 | -9 | 39 |
| 12 |
|
Aquila Montevarchi | 32 | 10 | 7 | 15 | 34:49 | -15 | 37 |
| 13 |
|
ACN Siena 1904 | 32 | 9 | 9 | 14 | 36:38 | -2 | 36 |
| 14 |
|
Olbia Calcio | 32 | 9 | 9 | 14 | 36:43 | -7 | 36 |
| 15 |
|
Teramo Calcio | 32 | 9 | 9 | 14 | 32:51 | -19 | 36 |
| 16 |
|
Fermana FC | 32 | 7 | 12 | 13 | 24:37 | -13 | 33 |
| 17 |
|
US Pistoiese | 32 | 6 | 11 | 15 | 31:47 | -16 | 29 |
| 18 |
|
Viterbese | 32 | 5 | 13 | 14 | 34:45 | -11 | 28 |
| 19 |
|
Imolese Calcio | 32 | 6 | 11 | 15 | 33:46 | -13 | 27 |
| 20 |
|
US Grosseto FC | 32 | 4 | 13 | 15 | 26:39 | -13 | 25 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
