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| 11.03.2022 | 20:30 | Lucchese | - | AC Reggiana 1919 | 1:0 (0:0) | |
| 12.03.2022 | 14:30 | Carrarese Calcio | - | Modena FC | 2:3 (0:1) | |
| 14:30 | Imolese Calcio | - | Virtus Entella | 1:1 (0:1) | ||
| 14:30 | ACN Siena 1904 | - | AS Gubbio | 1:2 (1:0) | ||
| 14:30 | Ancona 1905 | - | Viterbese | 2:2 (2:0) | ||
| 14:30 | US Pistoiese | - | Cesena FC | 0:1 (0:1) | ||
| 17:30 | Olbia Calcio | - | Delfino Pescara | 1:2 (1:0) | ||
| 17:30 | Teramo Calcio | - | Aquila Montevarchi | 0:1 (0:1) | ||
| 17:30 | US Pontedera | - | Fermana FC | 1:2 (0:1) | ||
| 17:30 | Vis Pesaro | - | US Grosseto FC | 2:1 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Modena FC | 31 | 23 | 5 | 3 | 55:21 | 34 | 74 |
| 2 |
|
AC Reggiana 1919 | 31 | 20 | 9 | 2 | 55:18 | 37 | 69 |
| 3 |
|
Cesena FC | 31 | 16 | 10 | 5 | 42:22 | 20 | 58 |
| 4 |
|
Virtus Entella | 31 | 15 | 8 | 8 | 53:34 | 19 | 53 |
| 5 |
|
Delfino Pescara | 31 | 14 | 11 | 6 | 46:34 | 12 | 53 |
| 6 |
|
Ancona 1905 | 31 | 13 | 8 | 10 | 52:41 | 11 | 47 |
| 7 |
|
AS Gubbio | 31 | 10 | 13 | 8 | 42:34 | 8 | 43 |
| 8 |
|
Vis Pesaro | 31 | 10 | 11 | 10 | 30:40 | -10 | 41 |
| 9 |
|
Lucchese | 31 | 9 | 12 | 10 | 29:30 | -1 | 39 |
| 10 |
|
US Pontedera | 31 | 11 | 6 | 14 | 34:45 | -11 | 39 |
| 11 |
|
Carrarese Calcio | 31 | 8 | 14 | 9 | 31:40 | -9 | 38 |
| 12 |
|
ACN Siena 1904 | 31 | 9 | 8 | 14 | 35:37 | -2 | 35 |
| 13 |
|
Olbia Calcio | 31 | 9 | 8 | 14 | 35:42 | -7 | 35 |
| 14 |
|
Aquila Montevarchi | 31 | 9 | 7 | 15 | 32:49 | -17 | 34 |
| 15 |
|
Teramo Calcio | 31 | 8 | 9 | 14 | 31:51 | -20 | 33 |
| 16 |
|
Fermana FC | 31 | 7 | 12 | 12 | 24:36 | -12 | 33 |
| 17 |
|
US Pistoiese | 31 | 6 | 10 | 15 | 29:45 | -16 | 28 |
| 18 |
|
Viterbese | 31 | 5 | 12 | 14 | 32:43 | -11 | 27 |
| 19 |
|
Imolese Calcio | 31 | 6 | 11 | 14 | 32:44 | -12 | 27 |
| 20 |
|
US Grosseto FC | 31 | 4 | 12 | 15 | 26:39 | -13 | 24 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
