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| 29.05.2022 | 15:00 | Cronenberger SC | - | 1. FC Mönchengladbach | 6:0 (3:0) | |
| 15:00 | SC Union Nettetal | - | TV Jahn Hiesfeld | 4:0 (1:0) | ||
| 15:00 | FC Kray | - | SC Velbert | 0:4 (0:2) | ||
| 15:00 | SC Düsseldorf-West | - | Sportfreunde Niederwenigern | 3:0 (1:0) | ||
| 15:30 | TuRU Düsseldorf | - | DJK Teutonia St. Tönis | 1:0 (0:0) | ||
| 15:30 | SpVgg Sterkrade-Nord | - | FSV Duisburg | 2:1 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Union Nettetal | 31 | 15 | 2 | 14 | 59:50 | 9 | 47 |
| 2 |
|
TuRU Düsseldorf | 31 | 12 | 9 | 10 | 46:48 | -2 | 45 |
| 3 |
|
TV Jahn Hiesfeld | 31 | 12 | 4 | 15 | 54:65 | -11 | 40 |
| 4 |
|
DJK Teutonia St. Tönis | 31 | 10 | 6 | 15 | 48:54 | -6 | 36 |
| 5 |
|
Cronenberger SC | 31 | 10 | 5 | 16 | 52:72 | -20 | 35 |
| 6 |
|
SC Düsseldorf-West | 31 | 9 | 7 | 15 | 44:59 | -15 | 34 |
| 7 |
|
SpVgg Sterkrade-Nord | 31 | 10 | 3 | 18 | 52:79 | -27 | 33 |
| 8 |
|
FC Kray | 31 | 9 | 5 | 17 | 44:73 | -29 | 32 |
| 9 |
|
FSV Duisburg | 31 | 8 | 7 | 16 | 40:47 | -7 | 31 |
| 10 |
|
Sportfreunde Niederwenigern | 31 | 8 | 6 | 17 | 47:79 | -32 | 30 |
| 11 |
|
SC Velbert | 31 | 7 | 6 | 18 | 42:78 | -36 | 27 |
| 12 |
|
1. FC Mönchengladbach | 31 | 3 | 4 | 24 | 39:99 | -60 | 13 |
| Degradatie | |
| Degradatie |
