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| 05.11.2021 | 19:30 | TuRU Düsseldorf | - | SSVg Velbert | 1:4 (0:1) | |
| 19:30 | VfB 03 Hilden | - | SC Düsseldorf-West | 4:2 (3:1) | ||
| 07.11.2021 | 15:00 | Germania Ratingen 04/19 | - | 1. FC Bocholt | 3:0 (2:0) | |
| 15:00 | 1. FC Monheim | - | TSV Meerbusch | 1:3 (1:1) | ||
| 15:00 | Sportfreunde Niederwenigern | - | Cronenberger SC | 1:1 (0:1) | ||
| 15:00 | FC Kray | - | SpVgg Sterkrade-Nord | 2:1 (1:0) | ||
| 15:00 | SC Velbert | - | SC Union Nettetal | 1:1 (1:0) | ||
| 15:00 | TV Jahn Hiesfeld | - | SpVg Schonnebeck | 0:3 (0:1) | ||
| 15:30 | DJK Teutonia St. Tönis | - | TVD Velbert | 2:0 (1:0) | ||
| 15:30 | 1. FC Mönchengladbach | - | 1. FC Kleve | 1:2 (0:2) | ||
| 15:30 | FSV Duisburg | - | Sportfreunde Baumberg | 0:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSVg Velbert | 11 | 9 | 2 | 0 | 32:9 | 23 | 29 |
| 2 |
|
VfB 03 Hilden | 11 | 9 | 1 | 1 | 29:10 | 19 | 28 |
| 3 |
|
1. FC Bocholt | 11 | 7 | 3 | 1 | 36:10 | 26 | 24 |
| 4 |
|
1. FC Kleve | 12 | 7 | 3 | 2 | 21:13 | 8 | 24 |
| 5 |
|
Germania Ratingen 04/19 | 12 | 7 | 2 | 3 | 32:18 | 14 | 23 |
| 6 |
|
1. FC Monheim | 12 | 7 | 2 | 3 | 23:11 | 12 | 23 |
| 7 |
|
SpVg Schonnebeck | 12 | 6 | 4 | 2 | 29:16 | 13 | 22 |
| 8 |
|
Sportfreunde Baumberg | 12 | 6 | 0 | 6 | 22:21 | 1 | 18 |
| 9 |
|
TSV Meerbusch | 11 | 6 | 0 | 5 | 21:22 | -1 | 18 |
| 10 |
|
TuRU Düsseldorf | 12 | 5 | 2 | 5 | 18:21 | -3 | 17 |
| 11 |
|
TVD Velbert | 11 | 5 | 1 | 5 | 16:18 | -2 | 16 |
| 12 |
|
Schwarz-Weiß Essen | 11 | 5 | 0 | 6 | 18:25 | -7 | 15 |
| 13 |
|
Sportfreunde Niederwenigern | 11 | 3 | 5 | 3 | 18:24 | -6 | 14 |
| 14 |
|
FC Kray | 12 | 4 | 2 | 6 | 18:29 | -11 | 14 |
| 15 |
|
SC Velbert | 11 | 3 | 4 | 4 | 19:16 | 3 | 13 |
| 16 |
|
SC Union Nettetal | 12 | 4 | 1 | 7 | 17:22 | -5 | 13 |
| 17 |
|
TV Jahn Hiesfeld | 11 | 3 | 2 | 6 | 15:18 | -3 | 11 |
| 18 |
|
DJK Teutonia St. Tönis | 12 | 3 | 2 | 7 | 16:25 | -9 | 11 |
| 19 |
|
1. FC Mönchengladbach | 11 | 3 | 1 | 7 | 14:30 | -16 | 10 |
| 20 |
|
Cronenberger SC | 12 | 2 | 4 | 6 | 13:29 | -16 | 10 |
| 21 |
|
FSV Duisburg | 11 | 2 | 2 | 7 | 12:17 | -5 | 8 |
| 22 |
|
SC Düsseldorf-West | 12 | 2 | 2 | 8 | 14:29 | -15 | 8 |
| 23 |
|
SpVgg Sterkrade-Nord | 11 | 1 | 1 | 9 | 13:33 | -20 | 4 |
| Play-offs | |
| Play-offs |
