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| 02.12.2021 | 19:30 | TSV Meerbusch | - | VfB 03 Hilden | 0:5 (0:3) | |
| 03.12.2021 | 19:30 | SSVg Velbert | - | 1. FC Mönchengladbach | 2:0 (1:0) | |
| 19:30 | SC Düsseldorf-West | - | TV Jahn Hiesfeld | 1:2 (0:0) | ||
| 20:00 | 1. FC Kleve | - | SC Velbert | 8:0 (1:0) | ||
| 04.12.2021 | 18:00 | SC Union Nettetal | - | SpVg Schonnebeck | 1:0 (0:0) | |
| 05.12.2021 | 15:00 | TVD Velbert | - | 1. FC Monheim | 1:1 (0:0) | |
| 15:00 | Schwarz-Weiß Essen | - | TuRU Düsseldorf | 0:0 (0:0) | ||
| 15:00 | Sportfreunde Baumberg | - | Sportfreunde Niederwenigern | 6:2 (3:2) | ||
| 15:00 | FC Kray | - | DJK Teutonia St. Tönis | 2:3 (1:0) | ||
| 15:15 | SpVgg Sterkrade-Nord | - | Germania Ratingen 04/19 | 2:0 (0:0) | ||
| 15:30 | 1. FC Bocholt | - | FSV Duisburg | 3:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSVg Velbert | 14 | 12 | 2 | 0 | 42:10 | 32 | 38 |
| 2 |
|
VfB 03 Hilden | 14 | 12 | 1 | 1 | 40:11 | 29 | 37 |
| 3 |
|
1. FC Bocholt | 14 | 10 | 3 | 1 | 49:13 | 36 | 33 |
| 4 |
|
1. FC Kleve | 15 | 8 | 4 | 3 | 30:18 | 12 | 28 |
| 5 |
|
SpVg Schonnebeck | 14 | 7 | 4 | 3 | 32:18 | 14 | 25 |
| 6 |
|
Sportfreunde Baumberg | 15 | 8 | 0 | 7 | 32:25 | 7 | 24 |
| 7 |
|
1. FC Monheim | 15 | 7 | 3 | 5 | 25:21 | 4 | 24 |
| 8 |
|
Germania Ratingen 04/19 | 15 | 7 | 2 | 6 | 34:27 | 7 | 23 |
| 9 |
|
TVD Velbert | 14 | 7 | 2 | 5 | 23:22 | 1 | 23 |
| 10 |
|
SC Union Nettetal | 15 | 7 | 1 | 7 | 23:23 | 0 | 22 |
| 11 |
|
TSV Meerbusch | 14 | 7 | 1 | 6 | 27:30 | -3 | 22 |
| 12 |
|
Schwarz-Weiß Essen | 14 | 6 | 2 | 6 | 22:26 | -4 | 20 |
| 13 |
|
TuRU Düsseldorf | 15 | 5 | 4 | 6 | 21:26 | -5 | 19 |
| 14 |
|
DJK Teutonia St. Tönis | 15 | 5 | 2 | 8 | 22:32 | -10 | 17 |
| 15 |
|
FC Kray | 14 | 4 | 3 | 7 | 21:33 | -12 | 15 |
| 16 |
|
TV Jahn Hiesfeld | 14 | 4 | 2 | 8 | 18:24 | -6 | 14 |
| 17 |
|
SC Düsseldorf-West | 15 | 4 | 2 | 9 | 19:31 | -12 | 14 |
| 18 |
|
Sportfreunde Niederwenigern | 14 | 3 | 5 | 6 | 20:34 | -14 | 14 |
| 19 |
|
SC Velbert | 14 | 3 | 4 | 7 | 19:29 | -10 | 13 |
| 20 |
|
Cronenberger SC | 14 | 3 | 4 | 7 | 16:32 | -16 | 13 |
| 21 |
|
FSV Duisburg | 14 | 2 | 4 | 8 | 14:22 | -8 | 10 |
| 22 |
|
1. FC Mönchengladbach | 14 | 3 | 1 | 10 | 18:41 | -23 | 10 |
| 23 |
|
SpVgg Sterkrade-Nord | 14 | 2 | 2 | 10 | 18:37 | -19 | 8 |
| Play-offs | |
| Play-offs |
