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| 27.08.2021 | 19:30 | SSVg Velbert | - | Sportfreunde Baumberg | 6:2 (3:1) | |
| 29.08.2021 | 15:00 | 1. FC Monheim | - | VfB 03 Hilden | 2:1 (1:1) | |
| 15:00 | Schwarz-Weiß Essen | - | Cronenberger SC | 2:1 (1:0) | ||
| 15:00 | FC Kray | - | SpVg Schonnebeck | 2:5 (2:3) | ||
| 15:00 | Germania Ratingen 04/19 | - | SC Velbert | 2:0 (1:0) | ||
| 15:00 | TVD Velbert | - | SC Düsseldorf-West | 2:1 (1:0) | ||
| 15:15 | SpVgg Sterkrade-Nord | - | SC Union Nettetal | 1:2 (1:1) | ||
| 15:30 | 1. FC Bocholt | - | 1. FC Kleve | 2:2 (1:1) | ||
| 15:30 | DJK Teutonia St. Tönis | - | TV Jahn Hiesfeld | 4:1 (2:1) | ||
| 15:30 | TuRU Düsseldorf | - | Sportfreunde Niederwenigern | 2:2 (1:1) | ||
| 15:30 | 1. FC Mönchengladbach | - | FSV Duisburg | 4:3 (2:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SpVg Schonnebeck | 2 | 2 | 0 | 0 | 10:2 | 8 | 6 |
| 2 |
|
SSVg Velbert | 2 | 2 | 0 | 0 | 9:3 | 6 | 6 |
| 3 |
|
TVD Velbert | 2 | 2 | 0 | 0 | 4:2 | 2 | 6 |
| 4 |
|
DJK Teutonia St. Tönis | 2 | 1 | 1 | 0 | 8:5 | 3 | 4 |
| 5 |
|
1. FC Bocholt | 2 | 1 | 1 | 0 | 5:2 | 3 | 4 |
| 6 |
|
1. FC Kleve | 2 | 1 | 1 | 0 | 4:3 | 1 | 4 |
| 7 |
|
FSV Duisburg | 2 | 1 | 0 | 1 | 5:4 | 1 | 3 |
| 8 |
|
1. FC Mönchengladbach | 1 | 1 | 0 | 0 | 4:3 | 1 | 3 |
|
SC Velbert | 2 | 1 | 0 | 1 | 4:3 | 1 | 3 | |
| 10 |
|
Cronenberger SC | 2 | 1 | 0 | 1 | 3:2 | 1 | 3 |
|
Germania Ratingen 04/19 | 2 | 1 | 0 | 1 | 3:2 | 1 | 3 | |
| 12 |
|
FC Kray | 2 | 1 | 0 | 1 | 6:6 | 0 | 3 |
| 13 |
|
SC Union Nettetal | 2 | 1 | 0 | 1 | 3:3 | 0 | 3 |
|
VfB 03 Hilden | 2 | 1 | 0 | 1 | 3:3 | 0 | 3 | |
| 15 |
|
1. FC Monheim | 2 | 1 | 0 | 1 | 2:3 | -1 | 3 |
| 16 |
|
Schwarz-Weiß Essen | 2 | 1 | 0 | 1 | 2:6 | -4 | 3 |
| 17 |
|
Sportfreunde Niederwenigern | 2 | 0 | 2 | 0 | 6:6 | 0 | 2 |
| 18 |
|
TuRU Düsseldorf | 2 | 0 | 1 | 1 | 3:6 | -3 | 1 |
| 19 |
|
SC Düsseldorf-West | 2 | 0 | 0 | 2 | 2:5 | -3 | 0 |
| 20 |
|
SpVgg Sterkrade-Nord | 2 | 0 | 0 | 2 | 1:4 | -3 | 0 |
| 21 |
|
TV Jahn Hiesfeld | 2 | 0 | 0 | 2 | 2:8 | -6 | 0 |
| 22 |
|
Sportfreunde Baumberg | 2 | 0 | 0 | 2 | 2:9 | -7 | 0 |
| 23 |
|
TSV Meerbusch | 1 | 0 | 0 | 1 | 1:2 | -1 | 0 |
| Play-offs | |
| Play-offs |
