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| 05.03.2022 | 16:00 | Sportfreunde Niederwenigern | - | TVD Velbert | 0:1 (0:0) | |
| 18:00 | 1. FC Mönchengladbach | - | DJK Teutonia St. Tönis | 0:7 (0:3) | ||
| 06.03.2022 | 15:00 | SC Velbert | - | SpVgg Sterkrade-Nord | 3:1 (0:1) | |
| 15:00 | SpVg Schonnebeck | - | 1. FC Bocholt | 0:5 (0:4) | ||
| 15:00 | 1. FC Monheim | - | TuRU Düsseldorf | 0:2 (0:1) | ||
| 15:00 | Cronenberger SC | - | TSV Meerbusch | 4:1 (0:1) | ||
| 15:30 | VfB 03 Hilden | - | Schwarz-Weiß Essen | 2:1 (2:0) | ||
| 15:30 | SC Düsseldorf-West | - | Sportfreunde Baumberg | 0:3 (0:3) | ||
| 15:30 | FSV Duisburg | - | FC Kray | 3:0 (1:0) | ||
| 16:00 | TV Jahn Hiesfeld | - | SSVg Velbert | 1:0 (0:0) | ||
| 23.03.2022 | 20:00 | SC Union Nettetal | - | 1. FC Kleve | 1:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSVg Velbert | 19 | 16 | 2 | 1 | 52:11 | 41 | 50 |
| 2 |
|
1. FC Bocholt | 19 | 15 | 3 | 1 | 69:16 | 53 | 48 |
| 3 |
|
VfB 03 Hilden | 19 | 14 | 2 | 3 | 47:17 | 30 | 44 |
| 4 |
|
1. FC Kleve | 20 | 12 | 4 | 4 | 45:24 | 21 | 40 |
| 5 |
|
Sportfreunde Baumberg | 20 | 12 | 1 | 7 | 47:32 | 15 | 37 |
| 6 |
|
TVD Velbert | 19 | 10 | 4 | 5 | 30:24 | 6 | 34 |
| 7 |
|
1. FC Monheim | 20 | 10 | 3 | 7 | 37:25 | 12 | 33 |
| 8 |
|
SpVg Schonnebeck | 19 | 9 | 5 | 5 | 44:28 | 16 | 32 |
| 9 |
|
Germania Ratingen 04/19 | 19 | 9 | 4 | 6 | 44:29 | 15 | 31 |
| 10 |
|
TuRU Düsseldorf | 19 | 8 | 5 | 6 | 26:26 | 0 | 29 |
| 11 |
|
TSV Meerbusch | 19 | 9 | 1 | 9 | 34:43 | -9 | 28 |
| 12 |
|
Schwarz-Weiß Essen | 19 | 8 | 2 | 9 | 30:35 | -5 | 26 |
| 13 |
|
SC Union Nettetal | 19 | 8 | 1 | 10 | 28:33 | -5 | 25 |
| 14 |
|
DJK Teutonia St. Tönis | 19 | 6 | 3 | 10 | 30:36 | -6 | 21 |
| 15 |
|
TV Jahn Hiesfeld | 19 | 6 | 2 | 11 | 26:35 | -9 | 20 |
| 16 |
|
Cronenberger SC | 19 | 5 | 5 | 9 | 25:41 | -16 | 20 |
| 17 |
|
FSV Duisburg | 19 | 5 | 4 | 10 | 25:28 | -3 | 19 |
| 18 |
|
SC Düsseldorf-West | 19 | 5 | 3 | 11 | 24:41 | -17 | 18 |
| 19 |
|
FC Kray | 19 | 5 | 3 | 11 | 25:47 | -22 | 18 |
| 20 |
|
SC Velbert | 19 | 4 | 4 | 11 | 24:45 | -21 | 16 |
| 21 |
|
Sportfreunde Niederwenigern | 19 | 3 | 5 | 11 | 23:48 | -25 | 14 |
| 22 |
|
SpVgg Sterkrade-Nord | 19 | 3 | 2 | 14 | 23:57 | -34 | 11 |
| 23 |
|
1. FC Mönchengladbach | 19 | 3 | 2 | 14 | 22:59 | -37 | 11 |
| Play-offs | |
| Play-offs |
