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| 13.03.2022 | 15:00 | Westfalia Rhynern | - | SG Finnentrop/Bamenohl | 2:0 (1:0) | |
| 15:00 | TuS Haltern | - | FCE Rheine | 2:3 (2:1) | ||
| 15:00 | SC Paderborn 07 II | - | TuS Ennepetal | 2:0 (0:0) | ||
| 15:00 | SpVgg Vreden | - | Hammer SpVg | 1:0 (0:0) | ||
| 15:00 | Holzwickeder SC | - | ASC 09 Dortmund | 1:5 (1:3) | ||
| 15:15 | Westfalia Herne | - | 1. FC Kaan-Marienborn | 2:5 (1:3) | ||
| 15:30 | TuS Erndtebrück | - | SG Wattenscheid 09 | 0:4 (0:1) | ||
| 31.03.2022 | 20:00 | RSV Meinerzhagen | - | Viktoria Clarholz | 0:0 (0:0) | |
| 07.04.2022 | 19:30 | Preußen Münster II | - | SV Schermbeck | 3:0 (1:0) | |
| 19:30 | FC Gütersloh | - | TSG Sprockhövel | 2:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Kaan-Marienborn | 18 | 13 | 3 | 2 | 48:17 | 31 | 42 |
| 2 |
|
SC Paderborn 07 II | 18 | 12 | 4 | 2 | 53:17 | 36 | 40 |
| 3 |
|
SG Wattenscheid 09 | 18 | 12 | 3 | 3 | 35:19 | 16 | 39 |
| 4 |
|
FC Gütersloh | 18 | 11 | 4 | 3 | 28:11 | 17 | 37 |
| 5 |
|
Westfalia Rhynern | 18 | 12 | 0 | 6 | 49:22 | 27 | 36 |
| 6 |
|
ASC 09 Dortmund | 19 | 11 | 3 | 5 | 46:32 | 14 | 36 |
| 7 |
|
FCE Rheine | 18 | 10 | 1 | 7 | 31:30 | 1 | 31 |
| 8 |
|
SV Schermbeck | 18 | 9 | 2 | 7 | 34:24 | 10 | 29 |
| 9 |
|
TuS Erndtebrück | 18 | 8 | 4 | 6 | 33:37 | -4 | 28 |
| 10 |
|
Sportfreunde Siegen | 18 | 7 | 6 | 5 | 30:31 | -1 | 27 |
| 11 |
|
SpVgg Vreden | 19 | 7 | 4 | 8 | 21:36 | -15 | 25 |
| 12 |
|
TSG Sprockhövel | 18 | 7 | 2 | 9 | 38:32 | 6 | 23 |
| 13 |
|
Preußen Münster II | 18 | 6 | 4 | 8 | 31:36 | -5 | 22 |
| 14 |
|
SG Finnentrop/Bamenohl | 18 | 4 | 7 | 7 | 32:40 | -8 | 19 |
| 15 |
|
TuS Ennepetal | 18 | 5 | 4 | 9 | 28:40 | -12 | 19 |
| 16 |
|
Hammer SpVg | 18 | 5 | 3 | 10 | 27:39 | -12 | 18 |
| 17 |
|
Viktoria Clarholz | 18 | 4 | 5 | 9 | 24:32 | -8 | 17 |
| 18 |
|
TuS Haltern | 18 | 4 | 3 | 11 | 23:33 | -10 | 15 |
| 19 |
|
Holzwickeder SC | 18 | 4 | 2 | 12 | 17:49 | -32 | 14 |
| 20 |
|
RSV Meinerzhagen | 18 | 4 | 1 | 13 | 25:46 | -21 | 13 |
| 21 |
|
Westfalia Herne | 18 | 1 | 3 | 14 | 20:50 | -30 | 6 |
| Play-offs | |
| Promotie en degradatie |
