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| 22.10.2021 | 19:30 | SG Wattenscheid 09 | - | TuS Ennepetal | 1:0 (1:0) | |
| 23.10.2021 | 15:00 | Preußen Münster II | - | SC Paderborn 07 II | 0:4 (0:3) | |
| 24.10.2021 | 15:00 | SpVgg Vreden | - | Holzwickeder SC | 1:0 (1:0) | |
| 15:00 | TSG Sprockhövel | - | 1. FC Kaan-Marienborn | 1:6 (0:3) | ||
| 15:00 | FCE Rheine | - | Viktoria Clarholz | 1:2 (0:1) | ||
| 15:00 | TuS Erndtebrück | - | RSV Meinerzhagen | 1:0 (0:0) | ||
| 15:00 | Hammer SpVg | - | SG Finnentrop/Bamenohl | 2:2 (2:1) | ||
| 15:00 | Sportfreunde Siegen | - | ASC 09 Dortmund | 1:1 (1:0) | ||
| 15:00 | FC Gütersloh | - | Westfalia Rhynern | 2:1 (2:0) | ||
| 15:00 | TuS Haltern | - | Westfalia Herne | 2:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Paderborn 07 II | 9 | 7 | 1 | 1 | 30:6 | 24 | 22 |
| 2 |
|
1. FC Kaan-Marienborn | 8 | 7 | 1 | 0 | 28:7 | 21 | 22 |
| 3 |
|
SG Wattenscheid 09 | 9 | 7 | 0 | 2 | 17:10 | 7 | 21 |
| 4 |
|
FCE Rheine | 9 | 6 | 0 | 3 | 13:12 | 1 | 18 |
| 5 |
|
FC Gütersloh | 8 | 5 | 2 | 1 | 14:7 | 7 | 17 |
| 6 |
|
Westfalia Rhynern | 9 | 5 | 0 | 4 | 26:15 | 11 | 15 |
| 7 |
|
ASC 09 Dortmund | 9 | 4 | 3 | 2 | 20:14 | 6 | 15 |
| 8 |
|
TSG Sprockhövel | 9 | 4 | 2 | 3 | 24:17 | 7 | 14 |
| 9 |
|
Sportfreunde Siegen | 9 | 3 | 3 | 3 | 12:13 | -1 | 12 |
|
TuS Haltern | 8 | 3 | 3 | 2 | 12:13 | -1 | 12 | |
| 11 |
|
TuS Erndtebrück | 8 | 3 | 3 | 2 | 11:14 | -3 | 12 |
| 12 |
|
SV Schermbeck | 8 | 3 | 2 | 3 | 15:11 | 4 | 11 |
| 13 |
|
TuS Ennepetal | 8 | 3 | 2 | 3 | 13:14 | -1 | 11 |
| 14 |
|
SpVgg Vreden | 9 | 3 | 2 | 4 | 9:21 | -12 | 11 |
| 15 |
|
Preußen Münster II | 8 | 3 | 1 | 4 | 12:17 | -5 | 10 |
| 16 |
|
Hammer SpVg | 9 | 2 | 2 | 5 | 16:20 | -4 | 8 |
| 17 |
|
Holzwickeder SC | 9 | 2 | 1 | 6 | 9:22 | -13 | 7 |
| 18 |
|
SG Finnentrop/Bamenohl | 8 | 1 | 3 | 4 | 10:21 | -11 | 6 |
| 19 |
|
Viktoria Clarholz | 8 | 1 | 2 | 5 | 10:16 | -6 | 5 |
| 20 |
|
RSV Meinerzhagen | 9 | 1 | 0 | 8 | 9:22 | -13 | 3 |
| 21 |
|
Westfalia Herne | 9 | 0 | 1 | 8 | 6:24 | -18 | 1 |
| Play-offs | |
| Promotie en degradatie |
