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| 26.08.2022 | 19:00 | 1. FC Köln II | - | Fortuna Düsseldorf II | 3:1 (1:1) | |
| 19:30 | Alemannia Aachen | - | Rot Weiss Ahlen | 1:0 (1:0) | ||
| 27.08.2022 | 14:00 | SV 19 Straelen | - | Preußen Münster | 0:2 (0:0) | |
| 14:00 | Bor. Mönchengladbach II | - | Wuppertaler SV | 0:0 (0:0) | ||
| 14:00 | 1. FC Bocholt | - | SG Wattenscheid 09 | 3:2 (2:2) | ||
| 14:00 | SC Wiedenbrück | - | Fortuna Köln | 0:1 (0:1) | ||
| 14:00 | SV Rödinghausen | - | Rot-Weiß Oberhausen | 5:1 (5:0) | ||
| 14:00 | SV Lippstadt 08 | - | 1. FC Düren | 3:0 (3:0) | ||
| 28.08.2022 | 14:00 | FC Schalke 04 II | - | 1. FC Kaan-Marienborn | 1:2 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Kaan-Marienborn | 6 | 5 | 1 | 0 | 12:5 | 7 | 16 |
| 2 |
|
Preußen Münster | 6 | 4 | 1 | 1 | 15:6 | 9 | 13 |
| 3 |
|
1. FC Düren | 6 | 4 | 1 | 1 | 10:8 | 2 | 13 |
| 4 |
|
SV Rödinghausen | 6 | 4 | 0 | 2 | 15:5 | 10 | 12 |
| 5 |
|
SV Lippstadt 08 | 6 | 4 | 0 | 2 | 11:8 | 3 | 12 |
| 6 |
|
Rot-Weiß Oberhausen | 6 | 3 | 1 | 2 | 12:15 | -3 | 10 |
| 7 |
|
Alemannia Aachen | 6 | 2 | 3 | 1 | 9:7 | 2 | 9 |
| 8 |
|
SC Wiedenbrück | 6 | 2 | 2 | 2 | 9:5 | 4 | 8 |
| 9 |
|
Rot Weiss Ahlen | 6 | 2 | 2 | 2 | 13:10 | 3 | 8 |
| 10 |
|
Wuppertaler SV | 6 | 1 | 4 | 1 | 9:7 | 2 | 7 |
| 11 |
|
FC Schalke 04 II | 6 | 2 | 1 | 3 | 6:8 | -2 | 7 |
| 12 |
|
1. FC Köln II | 6 | 2 | 1 | 3 | 11:14 | -3 | 7 |
| 13 |
|
Fortuna Düsseldorf II | 6 | 2 | 1 | 3 | 7:10 | -3 | 7 |
| 14 |
|
Bor. Mönchengladbach II | 6 | 1 | 3 | 2 | 8:7 | 1 | 6 |
| 15 |
|
Fortuna Köln | 6 | 1 | 2 | 3 | 2:7 | -5 | 5 |
| 16 |
|
1. FC Bocholt | 6 | 1 | 2 | 3 | 9:16 | -7 | 5 |
| 17 |
|
SG Wattenscheid 09 | 6 | 1 | 1 | 4 | 7:19 | -12 | 4 |
| 18 |
|
SV 19 Straelen | 6 | 0 | 0 | 6 | 1:9 | -8 | 0 |
| Promotie | |
| Degradatie | |
| Degradatie |
