| 1. Ronde | 15.08.2021 | 1. FSV Mainz 05 [A-jun] | - | Karlsruher SC [A-jun] | 1:3 | ||||
| 3. Ronde | 10.09.2021 | Karlsruher SC [A-jun] | - | FC-Astoria Walldorf [A-jun] | 0:0 | ||||
| 4. Ronde | 18.09.2021 | FC Ingolstadt 04 [A-jun] | - | Karlsruher SC [A-jun] | 2:2 | ||||
| 6. Ronde | 02.10.2021 | 1. FC Kaiserslautern [A-jun] | - | Karlsruher SC [A-jun] | 4:3 |  |
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| 5. Ronde | 13.11.2021 | Karlsruher SC [A-jun] | - | SpVgg Unterhaching [A-jun] | 0:0 | ||||
| 10. Ronde | 20.11.2021 | Kickers Offenbach [A-jun] | - | Karlsruher SC [A-jun] | 5:1 | ||||
| 11. Ronde | 26.11.2021 | Karlsruher SC [A-jun] | - | SC Freiburg [A-jun] | 1:1 | ||||
| 12. Ronde | 05.12.2021 | SSV Ulm 1846 [A-jun] | - | Karlsruher SC [A-jun] | 0:5 |
Duitsland