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| 10.09.2021 | 19:00 | Karlsruher SC | - | FC-Astoria Walldorf | 0:0 (0:0) | |
| 11.09.2021 | 11:00 | Hessen Kassel | - | Stuttgarter Kickers | 0:1 (0:0) | |
| 11:00 | Eintracht Frankfurt | - | 1. FC Heidenheim 1846 | 1:1 (0:1) | ||
| 11:00 | 1. FSV Mainz 05 | - | FC Ingolstadt 04 | 4:3 (2:1) | ||
| 12:00 | 1899 Hoffenheim | - | SV Darmstadt 98 | 7:1 (2:1) | ||
| 12:00 | VfB Stuttgart | - | Kickers Offenbach | 3:0 (1:0) | ||
| 12:30 | SpVgg Greuther Fürth | - | SpVgg Unterhaching | 1:1 (0:1) | ||
| 13:00 | 1. FC Saarbrücken | - | SC Freiburg | 0:3 (0:2) | ||
| 15:00 | 1. FC Nürnberg | - | 1. FC Kaiserslautern | 4:2 (1:1) | ||
| 04.11.2021 | 13:00 | FC Augsburg | - | SSV Ulm 1846 | 1:0 (1:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1899 Hoffenheim | 3 | 3 | 0 | 0 | 18:6 | 12 | 9 |
| 2 |
|
VfB Stuttgart | 3 | 3 | 0 | 0 | 10:0 | 10 | 9 |
| 3 |
|
1. FC Nürnberg | 3 | 3 | 0 | 0 | 9:5 | 4 | 9 |
| 4 |
|
FC Augsburg | 3 | 3 | 0 | 0 | 7:3 | 4 | 9 |
| 5 |
|
1. FSV Mainz 05 | 3 | 2 | 0 | 1 | 12:7 | 5 | 6 |
| 6 |
|
Eintracht Frankfurt | 3 | 1 | 1 | 1 | 10:5 | 5 | 4 |
| 7 |
|
Karlsruher SC | 2 | 1 | 1 | 0 | 3:1 | 2 | 4 |
| 8 |
|
SpVgg Unterhaching | 3 | 1 | 1 | 1 | 4:3 | 1 | 4 |
| 9 |
|
1. FC Heidenheim 1846 | 3 | 1 | 1 | 1 | 3:6 | -3 | 4 |
| 10 |
|
Bayern München | 2 | 1 | 0 | 1 | 4:2 | 2 | 3 |
| 11 |
|
SSV Ulm 1846 | 2 | 1 | 0 | 1 | 1:1 | 0 | 3 |
| 12 |
|
FC Ingolstadt 04 | 3 | 1 | 0 | 2 | 7:8 | -1 | 3 |
| 13 |
|
SC Freiburg | 3 | 1 | 0 | 2 | 6:7 | -1 | 3 |
| 14 |
|
Hessen Kassel | 3 | 1 | 0 | 2 | 3:4 | -1 | 3 |
| 15 |
|
Kickers Offenbach | 3 | 1 | 0 | 2 | 4:7 | -3 | 3 |
| 16 |
|
Stuttgarter Kickers | 3 | 1 | 0 | 2 | 6:13 | -7 | 3 |
| 17 |
|
SV Darmstadt 98 | 3 | 1 | 0 | 2 | 3:11 | -8 | 3 |
| 18 |
|
SpVgg Greuther Fürth | 3 | 0 | 2 | 1 | 3:4 | -1 | 2 |
| 19 |
|
FC-Astoria Walldorf | 3 | 0 | 2 | 1 | 2:8 | -6 | 2 |
| 20 |
|
1. FC Saarbrücken | 3 | 0 | 0 | 3 | 2:8 | -6 | 0 |
| 21 |
|
1. FC Kaiserslautern | 3 | 0 | 0 | 3 | 5:13 | -8 | 0 |
| Play-offs | |
| Degradatie |
