| 2. Ronde | 15.02.2022 | River Plate II | - | Patronato de Paraná II | 1:0 | ||||
| 3. Ronde | 19.02.2022 | Newell's Old Boys II | - | River Plate II | 1:2 | ||||
| 4. Ronde | 24.02.2022 | River Plate II | - | Racing Club II | 4:2 | ||||
| 5. Ronde | 04.03.2022 | San Lorenzo II | - | River Plate II | 0:4 | ||||
| 6. Ronde | 10.03.2022 | River Plate II | - | Gimnasia de La Plata II | 2:4 | ||||
| 7. Ronde | 18.03.2022 | River Plate II | - | Boca Juniors II | 0:0 | ||||
| 8. Ronde | 01.04.2022 | Defensa y Justicia II | - | River Plate II | 2:0 | ||||
| 10. Ronde | 14.04.2022 | Banfield II | - | River Plate II | 2:3 | ||||
| 11. Ronde | 20.04.2022 | Talleres de Córdoba II | - | River Plate II | 1:1 | ||||
| 12. Ronde | 25.04.2022 | River Plate II | - | Atlético Tucumán II | 4:0 | ||||
| 13. Ronde | 29.04.2022 | Sarmiento de Junín II | - | River Plate II | 1:2 | ||||
| 14. Ronde | 05.05.2022 | River Plate II | - | Platense II | 2:2 |  |
Argentinië