| 5. Ronde | 13.09.2021 | CD Lugo | - | SD Huesca | 3:2 | ||||
| 6. Ronde | 19.09.2021 | SD Huesca | - | CF Fuenlabrada | 0:0 |  |
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| 7. Ronde | 24.09.2021 | Real Sociedad B | - | SD Huesca | 0:2 |  |
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| 8. Ronde | 02.10.2021 | SD Huesca | - | CD Tenerife | 1:2 | ||||
| 9. Ronde | 11.10.2021 | Real Zaragoza | - | SD Huesca | 0:0 | |
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| 10. Ronde | 16.10.2021 | Girona FC | - | SD Huesca | 1:3 | ||||
| 12. Ronde | 24.10.2021 | Burgos CF | - | SD Huesca | 3:1 | ||||
| 13. Ronde | 30.10.2021 | SD Huesca | - | SD Amorebieta | 1:1 | ||||
| 14. Ronde | 02.11.2021 | SD Ponferradina | - | SD Huesca | 1:1 | ||||
| 15. Ronde | 05.11.2021 | SD Huesca | - | CD Leganés | 0:2 | ||||
| 18. Ronde | 27.11.2021 | UD Almería | - | SD Huesca | 0:0 | ||||
| 20. Ronde | 10.12.2021 | Sporting Gijón | - | SD Huesca | 1:1 | ||||
| 21. Ronde | 19.12.2021 | SD Huesca | - | AD Alcorcón | 0:0 | ||||
| 22. Ronde | 02.01.2022 | SD Huesca | - | Girona FC | 0:1 |
Paraguay