| 5. Ronde | 12.09.2021 | Etzella Ettelbruck | - | FC Rodange 91 | 3:0 | ||||
| 6. Ronde | 18.09.2021 | RM Hamm Benfica | - | Etzella Ettelbruck | 1:3 | ||||
| 7. Ronde | 22.09.2021 | Etzella Ettelbruck | - | FC Wiltz 71 | 3:1 | ||||
| 8. Ronde | 26.09.2021 | F91 Dudelange | - | Etzella Ettelbruck | 6:1 | ||||
| 9. Ronde | 17.10.2021 | Etzella Ettelbruck | - | Jeunesse Esch | 2:1 | ||||
| 10. Ronde | 03.11.2021 | US Hostert | - | Etzella Ettelbruck | 3:2 |  |
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| 11. Ronde | 07.11.2021 | Etzella Ettelbruck | - | RFCU Luxemburg | 1:2 | |
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| 12. Ronde | 21.11.2021 | Union Titus Pétange | - | Etzella Ettelbruck | 4:1 | ||||
| 13. Ronde | 28.11.2021 | Etzella Ettelbruck | - | US Mondorf | 2:1 | ||||
| 14. Ronde | 04.12.2021 | Progrès Niedercorn | - | Etzella Ettelbruck | 6:0 | ||||
| 15. Ronde | 12.12.2021 | FC Differdange 03 | - | Etzella Ettelbruck | 4:0 |
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